{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:04:25Z","timestamp":1790622265025,"version":"4.1.0"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"16","license":[{"start":{"date-parts":[[2009,8,15]],"date-time":"2009-08-15T00:00:00Z","timestamp":1250294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2009,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>New World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor. This first structure of an arenavirus glycoprotein shows that GP1 consists of a novel \u03b1\/\u03b2 fold. This provides a blueprint of the New World arenavirus attachment glycoproteins and reveals a new architecture of viral attachment, using a protein fold of unknown origins.<\/jats:p>","DOI":"10.1128\/jvi.00761-09","type":"journal-article","created":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T00:46:04Z","timestamp":1244076364000},"page":"8259-8265","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":76,"title":["Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein"],"prefix":"10.1128","volume":"83","author":[{"given":"Thomas A.","family":"Bowden","sequence":"first","affiliation":[{"name":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Crispin","sequence":"additional","affiliation":[{"name":"Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Yvonne","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Stuart","sequence":"additional","affiliation":[{"name":"Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000358"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444995008754"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.01.043"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/156800505774912884"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444906029799"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.18.2391"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01344-08"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0248"},{"key":"e_1_3_2_10_2","unstructured":"Arenaviridae: the viruses and their replication 2007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-7580-3-1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2008.10.016"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2007.01.011"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00202-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02053-3"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg500"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04288.x"},{"key":"e_1_3_2_18_2","first-page":"34","volume":"31","year":"1994","unstructured":"Cowtan, K. 1994. DM. Joint CCP4 ESF-EACBM Newsl. Protein Crystallogr.31:34-38.","journal-title":"Joint CCP4 ESF-EACBM Newsl. Protein Crystallogr."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.3.1290-1301.2006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm216"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(97)76073-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000047"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00008-06"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01397-07"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1142"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/15.4.305"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn507"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.4.12.1953"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/520607"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444996012255"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(97)76066-X"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444901014007"},{"key":"e_1_3_2_35_2","first-page":"103","volume":"14","year":"2004","unstructured":"Petrescu, A. J., A. L. Milac, S. M. Petrescu, R. A. Dwek, and M. R. Wormald. 2004. Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding. Glycobiology14:103-114.","journal-title":"Glycobiology"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05539"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709254105"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212519299"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.01113.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02392-07"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902011678"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400184200"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444905007808"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(99)80095-1"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti534"},{"key":"e_1_3_2_46_2","doi-asserted-by":"crossref","first-page":"ii246","DOI":"10.1093\/bioinformatics\/btg1086","volume":"19","year":"2003","unstructured":"Ye, Y., and A. Godzik. 2003. Flexible structure alignment by chaining aligned fragment pairs allowing twists. Bioinformatics19(Suppl. 2):ii246-ii255.","journal-title":"Bioinformatics"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi000432m"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00761-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00761-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T13:25:41Z","timestamp":1685021141000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00761-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,15]]},"references-count":46,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2009,8,15]]}},"alternative-id":["10.1128\/JVI.00761-09"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00761-09","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,15]]},"assertion":[{"value":"2009-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-08-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}