{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:37:21Z","timestamp":1771511841151,"version":"3.50.1"},"reference-count":69,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n            Hypoxia inducible factor 1\u03b1 (HIF-1\u03b1) and HIF-2\u03b1 are transcription factors which play important roles in the Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) latent and lytic gene replication. Herein, we show that the\n            <jats:italic>ORF34<\/jats:italic>\n            gene is involved in the regulation of KSHV lytic gene expression, since deletion of\n            <jats:italic>ORF34<\/jats:italic>\n            resulted in reduced immediate early and early lytic gene expression and blocked late gene expression. In addition, we demonstrate that the KSHV ORF34 protein binds and stabilizes HIF-2\u03b1, in contrast to its role in binding HIF-1\u03b1 and causing its degradation via the proteasome pathway. Thus, the KSHV ORF34 protein plays a regulatory role in the KSHV life cycle by regulating HIF-1\u03b1 and HIF-2\u03b1 expression.\n          <\/jats:p>","DOI":"10.1128\/jvi.00764-19","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T12:54:49Z","timestamp":1560344089000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["The Kaposi\u2019s Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2\u03b1 via Binding to the HIF-2\u03b1 bHLH and PAS Domains"],"prefix":"10.1128","volume":"93","author":[{"given":"Muzammel","family":"Haque","sequence":"first","affiliation":[{"name":"Division of Biotechnology and Molecular Medicine, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome. 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