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Here we report two new lipopeptide-based fusion inhibitors (LP-50 and LP-51) showing extremely potent inhibitory activities against diverse HIV-1, HIV-2, SIV, and T-20-resistant variants. Promisingly, both inhibitors exhibited potent and long-lasting\n            <jats:italic>ex vivo<\/jats:italic>\n            anti-HIV activity and could efficiently suppress viral loads to undetectable levels in SHIV-infected monkey models. We believe that LP-50 and LP-51 are the most potent and broad-spectrum fusion inhibitors known to date and thus have high potential for clinical development.\n          <\/jats:p>","DOI":"10.1128\/jvi.00775-18","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T10:00:11Z","timestamp":1528797611000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Design of Novel HIV-1\/2 Fusion Inhibitors with High Therapeutic Efficacy in Rhesus Monkey Models"],"prefix":"10.1128","volume":"92","author":[{"given":"Huihui","family":"Chong","sequence":"first","affiliation":[{"name":"MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"},{"name":"Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 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