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Zoonotic reservoirs (mainly pigs, wild boar, and deer) are considered for genotypes 3 and 4, which exist in temperate climates. In view of the association of several zoonotic viruses with bats, we analyzed 3,869 bat specimens from 85 different species and from five continents for hepevirus RNA. HEVs were detected in African, Central American, and European bats, forming a novel phylogenetic clade in the family<jats:named-content content-type=\"genus-species\">Hepeviridae<\/jats:named-content>. Bat hepeviruses were highly diversified and comparable to human HEV in sequence variation. No evidence for the transmission of bat hepeviruses to humans was found in over 90,000 human blood donations and individual patient sera. Full-genome analysis of one representative virus confirmed formal classification within the family<jats:named-content content-type=\"genus-species\">Hepeviridae<\/jats:named-content>. Sequence- and distance-based taxonomic evaluations suggested that bat hepeviruses constitute a distinct genus within the family<jats:named-content content-type=\"genus-species\">Hepeviridae<\/jats:named-content>and that at least three other genera comprising human, rodent, and avian hepeviruses can be designated. This may imply that hepeviruses invaded mammalian hosts nonrecently and underwent speciation according to their host restrictions. Human HEV-related viruses in farmed and peridomestic animals might represent secondary acquisitions of human viruses, rather than animal precursors causally involved in the evolution of human HEV.<\/jats:p>","DOI":"10.1128\/jvi.00800-12","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T03:02:34Z","timestamp":1339642954000},"page":"9134-9147","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":253,"title":["Bats Worldwide Carry Hepatitis E Virus-Related Viruses That Form a Putative Novel Genus within the Family Hepeviridae"],"prefix":"10.1128","volume":"86","author":[{"given":"Jan Felix","family":"Drexler","sequence":"first","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Seelen","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Max","family":"Corman","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Fumie Tateno","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Cottontail","sequence":"additional","affiliation":[{"name":"Institute of Experimental Ecology, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Melim Zerbinati","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Gloza-Rausch","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, Bonn, Germany"},{"name":"Noctalis, Centre for Bat Protection and Information, Bad Segeberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M.","family":"Klose","sequence":"additional","affiliation":[{"name":"Institute of Virology, University of Bonn Medical Centre, Bonn, Germany"},{"name":"Institute of Experimental Ecology, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaw","family":"Adu-Sarkodie","sequence":"additional","affiliation":[{"name":"Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel K.","family":"Oppong","sequence":"additional","affiliation":[{"name":"Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth K. 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