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Data from both HSV1 and PRV laboratories have identified a Rab6 secretory pathway for the transport of single enveloped viral particles from the\n            <jats:italic>trans<\/jats:italic>\n            -Golgi network within small vacuoles to the plasma membrane. In contrast, after secondary envelopment in fibroblasts or melanoma cells, multiple infectious VZV particles accumulated within large M6PR-positive late endosomes that were not degraded en route to the plasma membrane. We propose that this M6PR pathway is most utilized in VZV infection and least utilized in HSV1 infection, with PRV\u2019s usage being closer to HSV1\u2019s usage. Supportive data from other VZV, PRV, and HSV1 laboratories about evidence for two egress pathways are included.\n          <\/jats:p>","DOI":"10.1128\/jvi.00800-20","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T13:57:04Z","timestamp":1591106224000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Exocytosis of Progeny Infectious Varicella-Zoster Virus Particles via a Mannose-6-Phosphate Receptor Pathway without Xenophagy following Secondary Envelopment"],"prefix":"10.1128","volume":"94","author":[{"given":"James H.","family":"Girsch","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases\/Virology, Children\u2019s Hospital, University of Iowa, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallen","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases\/Virology, 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