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Here we have examined the role that IL-2 signaling plays in several aspects of a CD8<jats:sup>+<\/jats:sup>T cell response against murine gammaherpesvirus 68 (MHV-68). Exposure to MHV-68 causes a persistent infection, along with infectious mononucleosis, providing a model for studying these processes in mice. Our study indicates that CD25 is necessary for optimal expansion of the antigen-specific CD8<jats:sup>+<\/jats:sup>T cell response but not for the long-term memory response. Contrastingly, IL-2 signaling through CD25 is absolutely required for CD8<jats:sup>+<\/jats:sup>T cell mononucleosis.<\/jats:p>","DOI":"10.1128\/jvi.00856-10","type":"journal-article","created":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T03:53:47Z","timestamp":1280980427000},"page":"10923-10927","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Mononucleosis and Antigen-Driven T Cell Responses Have Different Requirements for Interleukin-2 Signaling in Murine Gammaherpesvirus Infection"],"prefix":"10.1128","volume":"84","author":[{"given":"Michael","family":"Molloy","sequence":"first","affiliation":[{"name":"Department of Microbiology &amp; Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon New Hampshire 03756"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon New Hampshire 03756"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Usherwood","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon New Hampshire 03756"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200637023"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.040575197"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.863"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.4049\/jimmunol.163.3.1481","volume":"163","year":"1999","unstructured":"Coppola, M. A., E. Flano, P. Nguyen, C. L. Hardy, R. D. Cardin, N. Shastri, D. L. Woodland, and M. A. Blackman. 1999. Apparent MHC-independent stimulation of CD8+ T cells in vivo during latent murine gammaherpesvirus infection. J. Immunol.163:1481-1489.","journal-title":"J. Immunol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.141"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb01010.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071135"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.2.1074"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4972"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1385\/IR:25:3:201"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.4049\/jimmunol.163.6.3403","volume":"163","year":"1999","unstructured":"Flano, E., D. L. Woodland, and M. A. 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