{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:18:40Z","timestamp":1792678720603,"version":"4.5.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"15","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia\/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator (Tax-1) contributes to leukemogenesis via NF-\u03baB. We describe transgenic\n                    <jats:named-content content-type=\"genus-species\">Drosophila<\/jats:named-content>\n                    models expressing Tax in the compound eye and plasmatocytes. We demonstrate that Tax-1 but not Tax-2 induces ommatidial perturbation and increased plasmatocyte proliferation and that the eye phenotype is dependent on Kenny (IKK\u03b3\/NEMO), thus validating this new\n                    <jats:italic>in vivo<\/jats:italic>\n                    model.\n                  <\/jats:p>","DOI":"10.1128\/jvi.00918-15","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T22:41:33Z","timestamp":1432161693000},"page":"8092-8095","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["A Transgenic Drosophila melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation\n                    <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"89","author":[{"given":"Margret","family":"Shirinian","sequence":"first","affiliation":[{"name":"Department of Experimental Pathology, Immunology, and Microbiology Faculty of Medicine, American University of Beirut, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakaria","family":"Kambris","sequence":"additional","affiliation":[{"name":"Department of Biology, American University of Beirut, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama","family":"Hamadeh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon"},{"name":"Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Grabbe","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Umea University, Umea, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Journo","sequence":"additional","affiliation":[{"name":"Equipe Oncogen\u00e8se R\u00e9trovirale, Lyon, France"},{"name":"Equipe Labellis\u00e9e, Ligue Nationale Contre le Cancer, Lyon, France"},{"name":"Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, Lyon, France"},{"name":"INSERM U1111 Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"},{"name":"Universit\u00e9 Lyon 1, LabEx ECOFECT-Eco-Evolutionary Dynamics of Infectious Diseases, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Mahieux","sequence":"additional","affiliation":[{"name":"Equipe Oncogen\u00e8se R\u00e9trovirale, Lyon, France"},{"name":"Equipe Labellis\u00e9e, Ligue Nationale Contre le Cancer, Lyon, France"},{"name":"Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, Lyon, France"},{"name":"INSERM U1111 Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"},{"name":"Universit\u00e9 Lyon 1, LabEx ECOFECT-Eco-Evolutionary Dynamics of Infectious Diseases, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon"},{"name":"Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2111"},{"key":"e_1_3_2_4_2","first-page":"144","article-title":"The epidemiology and disease outcomes of human T-lymphotropic virus type II","volume":"6","author":"Roucoux DF","year":"2004","unstructured":"Roucoux DF, Murphy EL. 2004. The epidemiology and disease outcomes of human T-lymphotropic virus type II. 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