{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T03:24:57Z","timestamp":1787714697313,"version":"build-2784847793"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Optic neuritis (ON), an inflammatory demyelinating optic nerve disease, occurs in multiple sclerosis (MS). Pathological mechanisms and potential treatments for ON have been studied via experimental autoimmune MS models. However, evidence suggests that virus-induced inflammation is a likely etiology triggering MS and ON; experimental virus-induced ON models are therefore required. We demonstrate that MHV-A59, a mouse hepatitis virus (MHV) strain that causes brain and spinal cord inflammation and demyelination, induces ON by promoting mixed inflammatory cell infiltration. In contrast, MHV-2, a nondemyelinating MHV strain, does not induce ON. Results reveal a reproducible virus-induced ON model important for the evaluation of novel therapies.<\/jats:p>","DOI":"10.1128\/jvi.00920-08","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T00:46:13Z","timestamp":1214441173000},"page":"8882-8886","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["Experimental Optic Neuritis Induced by a Demyelinating Strain of Mouse Hepatitis Virus"],"prefix":"10.1128","volume":"82","author":[{"given":"Kenneth S.","family":"Shindler","sequence":"first","affiliation":[{"name":"University of Pennsylvania, Scheie Eye Institute and FM Kirby Center for Molecular Ophthalmology, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence C.","family":"Kenyon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahasweta","family":"Dutt","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Scheie Eye Institute and FM Kirby Center for Molecular Ophthalmology, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan T.","family":"Hingley","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania 19131"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayasri Das","family":"Sarma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199303000-00001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20851"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.13.6115-6120.2001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/135502801753170282"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01488-07"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.040"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1344.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2004.tb00047.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/13550289609146902"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.62.6.1989-1998.1988"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(81)90010-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64537-3"},{"key":"e_1_3_2_14_2","first-page":"31","volume":"58","year":"1988","unstructured":"Lavi, E., P. 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