{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:54:59Z","timestamp":1770328499156,"version":"3.49.0"},"reference-count":73,"publisher":"American Society for Microbiology","issue":"21","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93019C00065"],"award-info":[{"award-number":["75N93019C00065"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93019C00067"],"award-info":[{"award-number":["75N93019C00067"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI139749"],"award-info":[{"award-number":["AI139749"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI101423"],"award-info":[{"award-number":["AI101423"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:p>To understand the crucial role of adaptive immunity in controlling cytomegalovirus infection and disease, we systematically analyzed the CMV \u201cORFeome\u201d to identify new CMV epitopes targeted primarily by CD4 T cells in humans. Our study identified &gt;200 new T cell epitopes derived from both canonical and novel ORFs, highlighting the substantial breadth of the anti-CMV T cell response and providing new targets for vaccine design.<\/jats:p>","DOI":"10.1128\/jvi.00940-21","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T18:34:34Z","timestamp":1628706874000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Profiling Human Cytomegalovirus-Specific T Cell Responses Reveals Novel Immunogenic Open Reading Frames"],"prefix":"10.1128","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-8657","authenticated-orcid":true,"given":"Rekha","family":"Dhanwani","sequence":"first","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep Kumar","family":"Dhanda","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Pham","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory P.","family":"Williams","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Sidney","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-5966","authenticated-orcid":true,"given":"Alba","family":"Grifoni","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaelle","family":"Picarda","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"},{"name":"Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia S.","family":"Lindestam Arlehamn","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"},{"name":"Department of Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris A.","family":"Benedict","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA"},{"name":"Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10080444"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014509107"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914430117"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18606-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02191.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2006.00199.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.1.77"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199612000-00010"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181e0ce05"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907083410203"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.027771-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.10.007"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/IDOG\/2006\/80383"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203053261003"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.09.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2005.09.016"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.spid.2004.09.011"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10080405"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1084-2756(02)90123-5"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00192-6"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000069767.43169.2d"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/516445"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2013.844653"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00030-18"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.02.089"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.7.1971.1971"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207013070102"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.5.1373.1373"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00352"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050882"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1086\/340637"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.10.8179-8184.1999"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4455"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/339963"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.9.5226-5240.2003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425203"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.02.005"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/587692"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227919"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2015.03.022"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1006"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2016.05.002"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169086"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.015"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005760"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd3871"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-7580-6-9"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-296"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/467852"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2012.03611.x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-568"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01369"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00202"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.098"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201249"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062424"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02128-16"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005832"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.1834"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02123-15"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-19-0886"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4631"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2628-4"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49894"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313.016"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800171"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903317116"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01925-13"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10120704"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.01.001"},{"key":"e_1_3_2_72_2","first-page":"1","article-title":"Human cytomegalovirus (HCMV) infection\/re-infection: development of a protective HCMV vaccine","volume":"42","author":"Gerna G","year":"2019","unstructured":"Gerna G, Lilleri D. 2019. Human cytomegalovirus (HCMV) infection\/re-infection: development of a protective HCMV vaccine. New Microbiol 42:1\u201320.","journal-title":"New Microbiol"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/763461"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf4063"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00940-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00940-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T16:30:39Z","timestamp":1646497839000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00940-21"}},"subtitle":[],"editor":[{"given":"Felicia","family":"Goodrum","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":73,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,10,13]]}},"alternative-id":["10.1128\/JVI.00940-21"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00940-21","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,13]]},"assertion":[{"value":"2021-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00940-21"}}