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The inactive, full-length Oas1b protein confers flavivirus-specific disease resistance. Although similar numbers of neurons were infected in resistant and susceptible brains after an intracranial virus infection, viral components amplified only in susceptible brains at later times. A line of resistant RNase L\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice was used to evaluate the contribution of RNase L to the resistance phenotype\n            <jats:italic>in vivo<\/jats:italic>\n            . Activation of RNase L antiviral activity by flavivirus infection was indicated by increased viral RNA levels in the brains of RNase L\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice.\n            <jats:italic>Oas1a<\/jats:italic>\n            and\n            <jats:italic>Oas1b<\/jats:italic>\n            mRNA levels were higher in infected RNase L\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice, indicating that activated RNase L also have a proflaviviral affect. However, the resistance phenotype was equally robust in RNase L\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            and RNase L\n            <jats:sup>+\/+<\/jats:sup>\n            mice.\n          <\/jats:p>","DOI":"10.1128\/jvi.00946-19","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T09:43:47Z","timestamp":1566985427000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["RNase L Antiviral Activity Is Not a Critical Component of the Oas1b-Mediated Flavivirus Resistance Phenotype"],"prefix":"10.1128","volume":"93","author":[{"suffix":"Jr.","given":"J. 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