{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:07:22Z","timestamp":1793329642016,"version":"4.5.0"},"reference-count":80,"publisher":"American Society for Microbiology","issue":"21","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n            Even though Sirt2, a NAD\n            <jats:sup>+<\/jats:sup>\n            -dependent protein deacetylase, is overexpressed in many HCCs, and overexpressed Sirt2 promotes hepatic fibrosis and associates positively with vascular invasion by primary HCCs through AKT\/GSK-3\u03b2\/\u03b2-catenin signaling, the relationship between Sirt2, HBV, HBx, and\/or HBV-associated hepatocarcinogenesis is unclear. Here, we show that HBV DNA replication, not HBV expression, correlates positively with Sirt2 upregulation and AKT activation. We demonstrate that overexpression of Sirt2 further increases HBV replication, increases AKT activation, downregulates GSK-3\u03b2, and increases \u03b2-catenin levels. Conversely, inhibiting Sirt2 decreases HBV replication, reduces AKT activation, and decreases \u03b2-catenin levels. Although HBx activates AKT to upregulate \u03b2-catenin, Sirt2-mediated effects were not dependent on HBx. The results also indicate that a Sirt2 inhibitor may control HBV infection and prevent the development of hepatic fibrosis and HCC.\n          <\/jats:p>","DOI":"10.1128\/jvi.00955-18","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T05:23:50Z","timestamp":1534397030000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["RETRACTED: Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis through the AKT\/GSK-3\u03b2\/\u03b2-Catenin Signaling Pathway"],"prefix":"10.1128","volume":"92","author":[{"given":"Zahra Zahid","family":"Piracha","sequence":"first","affiliation":[{"name":"Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea"},{"name":"Department of Biomedical Science, Graduate School of Ajou University, Suwon, South 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