{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:50:23Z","timestamp":1779299423918,"version":"3.51.4"},"reference-count":78,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI15383A"],"award-info":[{"award-number":["R21AI15383A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n            A new, safe, and effective vaccine against poliovirus is urgently needed not only to complete the eradication of the virus but also to be used in the future to prevent possible virus reemergence in a postpolio world. Currently, new formulations of the oral vaccine, as well as improvements to the inactivated vaccine, are being explored. In this study, we designed a viral vector with mucosal tropism that expresses poliovirus capsid proteins. Thus, poliovirus VLPs are produced\n            <jats:italic>in vivo<\/jats:italic>\n            , in the cells of a vaccine recipient, and are presented to the immune system in the context of vector virus replication, stimulating the development of systemic and mucosal immune responses. Such an approach allows the development of an affordable and safe vaccine that does not rely on the full-length poliovirus genome at any stage.\n          <\/jats:p>","DOI":"10.1128\/jvi.00976-18","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T09:39:38Z","timestamp":1529055578000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Newcastle Disease Virus-Based Vectored Vaccine against Poliomyelitis"],"prefix":"10.1128","volume":"92","author":[{"given":"Ekaterina G.","family":"Viktorova","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Khattar","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Kouiavskaia","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Laassri","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Zagorodnyaya","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Dragunsky","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siba","family":"Samal","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-6247","authenticated-orcid":false,"given":"Konstantin","family":"Chumakov","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Belov","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.09.015"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2015.1104"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.013"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.401"},{"key":"e_1_3_2_6_2","first-page":"358","article-title":"Update on vaccine-derived polioviruses detected worldwide, April 2011\u2013June 2012","volume":"87","year":"2012","unstructured":". 2012. Update on vaccine-derived polioviruses detected worldwide, April 2011\u2013June 2012. Wkly Epidemiol Rec 87:358\u2013368.","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.02.071"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16150-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2016.21.47.30408"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005114"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1635"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1726"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix117"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix133"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix116"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(88)90172-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(62)90205-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90522-Q"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.4.2088-2092.1991"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1067"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-70-6-1453"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560031005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006117"},{"key":"e_1_3_2_24_2","first-page":"1449","volume-title":"Fields virology","author":"Lamb RA","year":"2007","unstructured":"Lamb RA, Parks GD. 2007. Paramyxoviridae: the viruses and their replication, p 1449\u20131496. In Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (ed), Fields virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.","edition":"5"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/v8070183"},{"key":"e_1_3_2_26_2","volume-title":"The biology of paramyxoviruses, p 69\u2013114","author":"Samal SK","year":"2011","unstructured":"Samal SK. 2011. The biology of paramyxoviruses, p 69\u2013114. Caister Academic Press, Norfolk, United Kingdom."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703584104"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00713-07"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01946-09"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.10.024"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.08.016"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.21.13275-13284.2005"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2003.10.020"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320041110"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02553-10"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9046"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00840-07"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baw022"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01005-15"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05050-11"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02847-15"},{"key":"e_1_3_2_42_2","first-page":"1","article-title":"Poliomyelitis prevention in the United States: introduction of a sequential vaccination schedule of inactivated poliovirus vaccine followed by oral poliovirus vaccine. Recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"46","year":"1997","unstructured":". 1997. Poliomyelitis prevention in the United States: introduction of a sequential vaccination schedule of inactivated poliovirus vaccine followed by oral poliovirus vaccine. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 46:1\u201325.","journal-title":"MMWR Recomm Rep"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101317"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.26.4.732-738.1988"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.10.040"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00970.x"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot094474"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.11.015"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01586-16"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.7.20709"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1406250"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02675-06"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3292-4_7"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-3369-2_7"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.11.021"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122762"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.05.006"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1086\/657087"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1951.01700020099011"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.45.6.742"},{"key":"e_1_3_2_61_2","first-page":"622","article-title":"A case of human infection with Newcastle disease virus","volume":"7","author":"Mustaffa-Babjee A","year":"1976","unstructured":"Mustaffa-Babjee A, Ibrahim AL, Khim TS. 1976. A case of human infection with Newcastle disease virus. Southeast Asian J Trop Med Public Health 7:622\u2013624.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.140"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.11.048"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/v3081358"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19277-0"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/82.6.899"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.23.11868-11873.2001"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32621-6"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.10.5458-5465.2004"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01863914"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.10.4965-4975.2004"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-7-1729"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.14.6394-6400.2000"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2010.01482.x"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-42-38"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000216"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_3_2_78_2","volume-title":"Manual for the virological investigation of polio","year":"1997","unstructured":". 1997. Manual for the virological investigation of polio. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_79_2","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"2011","unstructured":"National Research Council. 2011. Guide for the care and use of laboratory animals, 8th ed. National Academies Press, Washington, DC.","edition":"8"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00976-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00976-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T14:40:17Z","timestamp":1646491217000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00976-18"}},"subtitle":[],"editor":[{"given":"Julie K.","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":78,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1128\/JVI.00976-18"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00976-18","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"2018-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00976-18"}}