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These flaviviruses are zoonotic and use animals, including birds, as amplifying and reservoir hosts. Avian Tembusu virus (TMUV) is an emerging mosquito-borne flavivirus that is pathogenic for many avian species and can infect cells derived from mammals and humans\n            <jats:italic>in vitro<\/jats:italic>\n            . Although not currently pathogenic for primates, the infection of duck industry workers and the potential risk of TMUV infection in immunocompromised individuals have been highlighted. Thus, the prevention of TMUV in flocks is important for both avian and mammalian health. Our study reveals the escape of TMUV from the first line of the host defense system in the arthropod-borne transmission route of arboviruses, possibly helping to extend our understanding of flavivirus infection in birds and refine the design of anti-TMUV therapeutics.\n          <\/jats:p>","DOI":"10.1128\/jvi.00978-19","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T09:46:01Z","timestamp":1566812761000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Avian Flavivirus Infection of Monocytes\/Macrophages by Extensive Subversion of Host Antiviral Innate Immune Responses"],"prefix":"10.1128","volume":"93","author":[{"given":"Yong","family":"Ma","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People\u2019s Republic of 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