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The virus alters a diverse range of cellular molecules, which leads to B-cell growth and immortalization. This study was initiated to investigate the interplay between EBV and a proapoptotic transcription factor target, FoxO1. In this report, we show that EBV infection of B cells leads to the downregulation of FoxO1 expression by phosphatidylinositol 3-kinase-mediated nuclear export, by inhibition of FoxO1 mRNA expression, and by alteration of posttranslational modifications. This repression directly correlates with the expression of the FoxO1 target gene\n            <jats:italic>Bcl-6<\/jats:italic>\n            and inversely correlates with the FoxO1-regulated gene\n            <jats:italic>Cyclin D2<\/jats:italic>\n            . Expression of the EBV genes for latent membrane protein 1 and latent membrane protein 2A decreases FoxO1 expression. Thus, our data elucidate distinct mechanisms for the regulation of the proapoptotic transcription factor FoxO1 by EBV.\n          <\/jats:p>","DOI":"10.1128\/jvi.00983-06","type":"journal-article","created":{"date-parts":[[2006,10,28]],"date-time":"2006-10-28T00:12:28Z","timestamp":1161994348000},"page":"11191-11199","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Epstein-Barr Virus Represses the FoxO1 Transcription Factor through Latent Membrane Protein 1 and Latent Membrane Protein 2A"],"prefix":"10.1128","volume":"80","author":[{"given":"Angharad M.","family":"Shore","sequence":"first","affiliation":[{"name":"Medical Biochemistry and Immunology, Henry Wellcome Research Building, Cardiff University, Heath Park, Cardiff CF14 4XX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"White","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Immunology, Henry Wellcome Research Building, Cardiff University, Heath Park, Cardiff CF14 4XX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaline C.-Y.","family":"Hui","sequence":"additional","affiliation":[{"name":"Cancer Research UK Labs and Department of Oncology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkader","family":"Essafi","sequence":"additional","affiliation":[{"name":"Cancer Research UK Labs and Department of Oncology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric W.-F.","family":"Lam","sequence":"additional","affiliation":[{"name":"Cancer Research UK Labs and Department of Oncology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rowe","sequence":"additional","affiliation":[{"name":"CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston B15 2TJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brennan","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Immunology, Henry Wellcome Research Building, Cardiff University, Heath Park, Cardiff CF14 4XX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.12.5257.bloodjournal87125257"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190105"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7421"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0310292"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1200814"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.2001.0408"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205182"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3200975"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80595-4"},{"key":"e_1_3_2_11_2","first-page":"747","volume":"91","year":"1998","unstructured":"Carbone, A., G. 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