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In these cancers the viral genome is predominantly latent; i.e., most viral genes are not expressed, most viral proteins are not synthesized, and new virions are not produced. Some strategies for treating these cancers involve activation of lytic viral gene expression. We identify an antibacterial antibiotic, clofoctol, that is an activator of EBV lytic RNA and protein expression but that does not lead to virion production.<\/jats:p>","DOI":"10.1128\/jvi.00998-19","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T09:29:53Z","timestamp":1563960593000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacologic Activation of Lytic Epstein-Barr Virus Gene Expression without Virion Production"],"prefix":"10.1128","volume":"93","author":[{"given":"Jaeyeun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Kosowicz","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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