{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:18:40Z","timestamp":1768702720431,"version":"3.49.0"},"reference-count":79,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201400008C"],"award-info":[{"award-number":["HHSN272201400008C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI117873"],"award-info":[{"award-number":["U19AI117873"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,12,12]]},"abstract":"<jats:p>Influenza A viruses (IAVs) cause seasonal epidemics which result in an important health and economic burden. Wild aquatic birds are the natural host of IAV. However, IAV can infect diverse hosts, including humans, domestic poultry, pigs, and others. IAVs circulating in animals occasionally cross the species barrier, infecting humans, which results in mild to very severe disease. In some cases, these viruses can acquire the ability to be transmitted among humans and initiate a pandemic. The nonstructural 1 (NS1) protein of IAV is an important antagonist of the innate immune response. In this study, using recombinant viruses and primary human cells, we show that NS1 proteins from human and avian hosts show intrinsic differences in the modulation of the innate immunity in human dendritic cells and epithelial cells, as well as different cellular localization dynamics in infected cells.<\/jats:p>","DOI":"10.1128\/jvi.00999-19","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T15:25:24Z","timestamp":1570721124000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1"],"prefix":"10.1128","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-6849","authenticated-orcid":false,"given":"Paula L.","family":"Monteagudo","sequence":"first","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Mu\u00f1oz-Moreno","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Fribourg","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Potla","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Mena","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Marjanovic","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris M.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart C.","family":"Sealfon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Garc\u00eda-Sastre","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"},{"name":"Department of Medicine Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, New York, USA"},{"name":"Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-0120","authenticated-orcid":false,"given":"Irene","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3405-6702","authenticated-orcid":false,"given":"Ana","family":"Fern\u00e1ndez-Sesma","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"},{"name":"Department of Medicine Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, New York, USA"},{"name":"The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3665"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410592200"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400937101"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.01.021"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.020"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.025"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608618200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.09.108"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.12.006"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2014_400"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-1702(98)00011-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.05.026"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/v1031057"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.2008\/004606-0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.069542-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01265-06"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2015.08.007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.04.006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003059"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.17.7989-7996.2000"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.24.11566-11573.2000"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602184103"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.13.6203-6206.2000"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.2425-2433.1999"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.9937"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.01.038"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1998.18.757"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805213105"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02581-06"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0042-6822(02)00127-7"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(00)80099-4"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.8.2273"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06310.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.4.2425-2432.1994"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.20.17.6259-6268.2000"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19487-0"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.11.2241"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606109103"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910715107"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0071-y"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.62.8.3020-3026.1988"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.4864"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4123363"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02381-05"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02323-08"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000193"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02247-12"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.3380257"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.24.13257-13266.2003"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1017\/s1355838299981621"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.10.5.2327"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3791\/51284"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7535-7543.2005"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415570968"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33354"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03005-12"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00989-07"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001106"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.031575198"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm757"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801070"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03692-13"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.60.070191.003441"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.09.012"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02063-12"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084673"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01714-06"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.035485-0"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.69"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063270"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00203-10"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2017.08.011"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-167"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.024943-0"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.11.9679-9682.1999"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1754"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2010.12.014"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0034"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00999-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.00999-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:03:21Z","timestamp":1646492601000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.00999-19"}},"subtitle":[],"editor":[{"given":"Bryan RG.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,12]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12,12]]}},"alternative-id":["10.1128\/JVI.00999-19"],"URL":"https:\/\/doi.org\/10.1128\/jvi.00999-19","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,12]]},"assertion":[{"value":"2019-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00999-19"}}