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In most patients, infection results in high fever, rash, and incapacitating (chronic) arthralgia. CHIKV effectively inhibits the first line of defense, the innate immune response. As a result, stimulation of the innate immune response with interferons (IFNs) is ineffective as a treatment for CHIKV disease. The IFN response requires an intact downstream signaling cascade called the JAK\/STAT signaling pathway, which is effectively inhibited by CHIKV nonstructural protein 2 (nsP2) via an unknown mechanism. The research described here specifies where in the JAK\/STAT signaling cascade the IFN response is inhibited and which protein domain of nsP2 is responsible for IFN inhibition. The results illuminate new aspects of antiviral defense and CHIKV counterdefense strategies and will direct the search for novel antiviral compounds.<\/jats:p>","DOI":"10.1128\/jvi.01008-18","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T10:19:41Z","timestamp":1529403581000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["The Methyltransferase-Like Domain of Chikungunya Virus nsP2 Inhibits the Interferon Response by Promoting the Nuclear Export of STAT1"],"prefix":"10.1128","volume":"92","author":[{"given":"Giel P.","family":"G\u00f6ertz","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Wageningen University, Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"McNally","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, Rocky 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