{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:17:15Z","timestamp":1792048635251,"version":"4.4.0"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2016-67021-25042"],"award-info":[{"award-number":["2016-67021-25042"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001395","name":"Wisconsin Alumni Research Foundation","doi-asserted-by":"publisher","award":["2019-AAG6149"],"award-info":[{"award-number":["2019-AAG6149"]}],"id":[{"id":"10.13039\/100001395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,9,15]]},"abstract":"<jats:p>According to 2017 U.S. agriculture statistics, the combined value of production and sales from broilers, eggs, turkeys, and chicks was $42.8 billion. Of this number, broiler sales comprised 67% of the industry value, with the production of\u2009&gt;50 billion pounds of chicken meat. The economic success of the poultry industry in the United States hinges on the extensive use of vaccines to control infectious bronchitis virus (IBV) and other poultry pathogens. The majority of vaccines currently licensed for poultry health include both modified live vaccine and inactivated pathogens. Despite their proven efficacy, modified live vaccine constructs take time to produce and could revert to virulence, which limits their safety. The significance of our research stems from the development of a safer and potent alternative mucosal vaccine to replace live vaccines against IBV and other emerging coronaviruses.<\/jats:p>","DOI":"10.1128\/jvi.01016-20","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T14:29:13Z","timestamp":1594736953000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["A Novel Mucosal Adjuvant System for Immunization against Avian Coronavirus Causing Infectious Bronchitis"],"prefix":"10.1128","volume":"94","author":[{"given":"Shaswath S.","family":"Chandrasekar","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brock","family":"Kingstad-Bakke","sequence":"additional","affiliation":[{"name":"Pan Genome Systems, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3305-7903","authenticated-orcid":false,"given":"Adel M.","family":"Talaat","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA"},{"name":"Pan Genome Systems, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2012.680432"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4161\/bbug.18983"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01242547"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.20506\/rst.19.2.1228"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.11.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2010.09.002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1637\/10346-090412-Reg.1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-635X2010000200004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079459708419194"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079450500096539"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1637\/8465-090308-Reg.1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2307\/1590639"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.01.006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-1702(01)00345-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1690918"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-019-0698-z"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2003.01140.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.08.023"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1637\/0005-2086(2003)047[0272:POCFIB]2.0.CO;2"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2010.03.016"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.09.022"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.09.125"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2008.01.017"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-009-0424-7"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2013.14.1.53"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.001585"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1586\/erv.10.89"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.04.037"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.06.077"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.03.002"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm800276d"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.2007.B0153"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.10.7889-7894.1997"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2015.0027"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0145-305x(99)00072-5"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0211"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235688100"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.20506\/rst.26.1.1742"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30356-2"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079458708436391"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(01)00248-3"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2014.974504"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/7385"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02874"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6cs00636a"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.11.135"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics9040053"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00368-15"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02534.x"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2007.04.010"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.08.022"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157041"},{"key":"e_1_3_2_54_2","first-page":"493","article-title":"A simple method of estimating fifty percent endpoint","volume":"27","author":"Reed LJ","year":"1938","unstructured":"Reed LJ, Muench H. 1938. A simple method of estimating fifty percent endpoint. Am J Hyg 27:493\u2013497.","journal-title":"Am J Hyg"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079450500112344"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1637\/10740-120313-Reg.1"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01016-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01016-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:00:13Z","timestamp":1646492413000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01016-20"}},"subtitle":[],"editor":[{"given":"Tom","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,15]]},"references-count":55,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2020,9,15]]}},"alternative-id":["10.1128\/JVI.01016-20"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01016-20","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,15]]},"assertion":[{"value":"2020-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01016-20"}}