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Insights into these mechanisms can be gathered from large-animal models, where lymphatic cannulation from individual lymph nodes is possible. In this study, we assessed in vivo lymphocyte trafficking in bovine leukemia virus (BLV)-infected sheep. With a carboxyfluorescein diacetate succinimidyl ester labeling technique, we demonstrate that the dynamics of lymphocyte recirculation is unaltered but that accelerated proliferation in the lymphoid tissues is compensated for by increased death in the peripheral blood cell population. Lymphocyte homeostasis is thus maintained by biphasic kinetics in two distinct tissues, emphasizing a very dynamic process during BLV infection.<\/jats:p>","DOI":"10.1128\/jvi.01022-06","type":"journal-article","created":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T03:35:27Z","timestamp":1158204927000},"page":"9710-9719","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Peripheral Blood B-Cell Death Compensates for Excessive Proliferation in Lymphoid Tissues and Maintains Homeostasis in Bovine Leukemia Virus-InfectedSheep"],"prefix":"10.1128","volume":"80","author":[{"given":"Christophe","family":"Debacq","sequence":"first","affiliation":[{"name":"Molecular and Cellular Biology, FNRS-FUSAG, Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Gillet","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Biology, FNRS-FUSAG, Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becca","family":"Asquith","sequence":"additional","affiliation":[{"name":"Department of Immunology, Imperial College, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Sanchez-Alcaraz","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Florins","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Biology, FNRS-FUSAG, Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Boxus","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Biology, FNRS-FUSAG, Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Schwartz-Cornil","sequence":"additional","affiliation":[{"name":"U892 INRA, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Bonneau","sequence":"additional","affiliation":[{"name":"U892 INRA, Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevie\u0300ve","family":"Jean","sequence":"additional","affiliation":[{"name":"Zootechny Unit, FUSAG, Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Kerkhofs","sequence":"additional","affiliation":[{"name":"Department of Virology, Veterinary and Agrochemical Research Centre, Uccle, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Hay","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre\u0301","family":"The\u0301wis","sequence":"additional","affiliation":[{"name":"Zootechny Unit, FUSAG, Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kettmann","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Biology, FNRS-FUSAG, Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Willems","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Biology, FNRS-FUSAG, Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"68","volume":"252","year":"2000","unstructured":"Agenes, F., M. 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