{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:22:57Z","timestamp":1791238977563,"version":"4.1.0"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"23","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Coxsackievirus is the most important cause of meningitis and encephalitis in infants; an infection is sometimes fatal or may lead to neurodevelopmental defects. Here, we show that coxsackievirus B4 (CVB4) induces an autophagy pathway for replication in rat primary neurons. Notably, calpain inhibitors reduce autophagosome formation. Conversely, the inhibition of the autophagy pathway with 3-methyladenine inhibits calpain activation. This work reveals, for the first time, that calpain is essential for the autophagy pathway and viral replication in CVB4-infected neurons.<\/jats:p>","DOI":"10.1128\/jvi.01028-08","type":"journal-article","created":{"date-parts":[[2008,9,18]],"date-time":"2008-09-18T14:38:07Z","timestamp":1221748687000},"page":"11976-11978","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":77,"title":["Coxsackievirus B4 Uses Autophagy for Replication after Calpain Activation in Rat Primary Neurons"],"prefix":"10.1128","volume":"82","author":[{"given":"Seung Yong","family":"Yoon","sequence":"first","affiliation":[{"name":"Departments of Anatomy and Cell Biology"},{"name":"Research Institute for Biomacromolecules, University of Ulsan College of Medicine, Ulsan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Eun","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center"},{"name":"Sungkyunkwan University School of Medicine, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Cell Biology"},{"name":"Research Institute for Biomacromolecules, University of Ulsan College of Medicine, Ulsan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Microbiology"},{"name":"Research Institute for Biomacromolecules, University of Ulsan College of Medicine, Ulsan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heuiran","family":"Lee","sequence":"additional","affiliation":[{"name":"Microbiology"},{"name":"Research Institute for Biomacromolecules, University of Ulsan College of Medicine, Ulsan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Seok","family":"Kweon","sequence":"additional","affiliation":[{"name":"Division of Electron Microscopic Research, Korea Basic Science Institute, Daejeon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Electron Microscopic Research, Korea Basic Science Institute, Daejeon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hou","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Cell Biology"},{"name":"Research Institute for Biomacromolecules, University of Ulsan College of Medicine, Ulsan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00143-07"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200601024"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.05.019"},{"key":"e_1_3_2_5_2","first-page":"1019","volume":"98","year":"2001","unstructured":"Euscher, E., J. 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