{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:01:36Z","timestamp":1792069296987,"version":"4.4.0"},"reference-count":89,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:p>\n                    In recent outbreaks, ZIKV has infected millions of people and induced rare but potentially severe complications, including Guillain-Barr\u00e9 syndrome and encephalitis in adults. While several viral sequence variants were proposed to enhance the pathogenicity of ZIKV, the influence of host genetic variants in mediating the clinical heterogeneity remains mostly unexplored. We addressed this question using a mouse panel which models the genetic diversity of the human population and a ZIKV strain from a recent clinical isolate. Through a combination of\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    approaches, we demonstrate that multiple host genetic variants determine viral replication in infected cells and the clinical severity, the kinetics of blood viral load, and brain pathology in mice. We describe new mouse models expressing high degrees of susceptibility or resistance to ZIKV and to other flaviviruses. These models will facilitate the identification and mechanistic characterization of host genes that influence ZIKV pathogenesis.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01034-19","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T06:53:07Z","timestamp":1573109587000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of\n                    <i>Oas1b<\/i>"],"prefix":"10.1128","volume":"94","author":[{"given":"Caroline","family":"Manet","sequence":"first","affiliation":[{"name":"Mouse Genetics Laboratory, Department of Genomes and Genetics, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Simon-Lori\u00e8re","sequence":"additional","affiliation":[{"name":"Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Jouvion","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Pathophysiology of Pediatric Genetic Diseases, AP-HP, H\u00f4pital Armand-Trousseau, UF de G\u00e9n\u00e9tique Mol\u00e9culaire, Paris, France"},{"name":"Institut Pasteur, Experimental Neuropathology Unit, Department of Global Health, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hardy","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Experimental Neuropathology Unit, Department of Global Health, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Prot","sequence":"additional","affiliation":[{"name":"Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurine","family":"Conquet","sequence":"additional","affiliation":[{"name":"Mouse Genetics Laboratory, Department of Genomes and Genetics, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Flamand","sequence":"additional","affiliation":[{"name":"Structural Virology Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Panthier","sequence":"additional","affiliation":[{"name":"Mouse Genetics Laboratory, Department of Genomes and Genetics, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anavaj","family":"Sakuntabhai","sequence":"additional","affiliation":[{"name":"Functional Genetics of Infectious Diseases Unit, Department of Global Health, CNRS UMR 2000, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9372-5398","authenticated-orcid":false,"given":"Xavier","family":"Montagutelli","sequence":"additional","affiliation":[{"name":"Mouse Genetics Laboratory, Department of Genomes and Genetics, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602113"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0950268818000419"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00562-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix511"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1604338"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.01.012"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02816-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22365"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Flamand C Fritzell C Matheus S Dueymes M Carles G Favre A Enfissi A Adde A Demar M Kazanji M Cauchemez S Rousset D. 2017. 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