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The coordination between the microbiota and the immune system through bidirectional interactions regulates the impact of microorganisms on the host. Our research focused on understanding the relationships between substantial changes in jejunal intestinal flora and metabolites and intestinal immunity during porcine epidemic diarrhea virus (PEDV) infection in piglets. We discovered that\n                      <jats:italic>Lactobacillus rhamnosus GG<\/jats:italic>\n                      (\n                      <jats:italic>LGG<\/jats:italic>\n                      ) could effectively prevent PEDV infection in piglets. Further investigation revealed that\n                      <jats:italic>LGG<\/jats:italic>\n                      metabolites interact with type 3 innate lymphoid cells (ILC3s) in the jejunum of piglets through the aryl hydrocarbon receptor (AhR). This interaction promotes the activation of ILC3s and the production of interleukin-22 (IL-22). Subsequently, IL-22 facilitates the proliferation of IPEC-J2 cells and activates the STAT3 signaling pathway, thereby preventing PEDV infection. Moreover, the AhR receptor influences various cell types within organoids, including intestinal stem cells (ISCs), Paneth cells, and enterocytes, to promote their growth and development, suggesting that AhR has a broad impact on intestinal health. In conclusion, our study demonstrated the ability of\n                      <jats:italic>LGG<\/jats:italic>\n                      to modulate intestinal immunity and effectively prevent PEDV infection in piglets. These findings highlight the potential application of\n                      <jats:italic>LGG<\/jats:italic>\n                      as a preventive measure against viral infections in livestock.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        We observed high expression of the AhR receptor on pig and human ILC3s, although its expression was negligible in mouse ILC3s. ILC3s are closely related to the gut microbiota, particularly the secretion of IL-22 stimulated by microbial signals, which plays a crucial regulatory role in intestinal immunity. In our study, we found that metabolites produced by beneficial gut bacteria interact with ILC3s through AhR, thereby maintaining intestinal immune homeostasis in pigs. Moreover,\n                        <jats:italic>LGG<\/jats:italic>\n                        feeding can enhance the activation of ILC3s and promote IL-22 secretion in the intestines of piglets, ultimately preventing PEDV infection.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/jvi.01039-24","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T09:01:31Z","timestamp":1721120491000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["AhR ligands from\n                    <i>LGG<\/i>\n                    metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection"],"prefix":"10.1128","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7714-5257","authenticated-orcid":false,"given":"Junhong","family":"Wang","sequence":"first","affiliation":[{"name":"College 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