{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:37:47Z","timestamp":1792798667444,"version":"4.5.0"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KO 1579\/8-2"],"award-info":[{"award-number":["KO 1579\/8-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHA 1950\/1-1"],"award-info":[{"award-number":["SCHA 1950\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n            Human herpesviruses pose a constant threat to human health. Reactivation of persisting herpesvirus infections, particularly in immunocompromised individuals and the elderly, can cause severe diseases, such as zoster, pneumonia, encephalitis, or cancer. The interferon system is relevant for the control of herpesvirus replication as exemplified by fatal disease outcomes in patients with primary immunodeficiencies. Here, we describe the interferon-induced, human\n            <jats:italic>MX2<\/jats:italic>\n            gene product MxB as an efficient restriction factor of alpha-, beta-, and gammaherpesviruses. MxB has previously been described as an inhibitor of HIV-1. Importantly, our mutational analyses of MxB reveal an antiviral mechanism of herpesvirus restriction distinct from that against HIV-1. Thus, the dynamin-like MxB GTPase serves as a broadly acting intracellular restriction factor that controls retrovirus as well as herpesvirus infections.\n          <\/jats:p>","DOI":"10.1128\/jvi.01056-18","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T13:33:39Z","timestamp":1529933619000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":112,"title":["Human MxB Protein Is a Pan-herpesvirus Restriction Factor"],"prefix":"10.1128","volume":"92","author":[{"given":"Mirjam","family":"Schilling","sequence":"first","affiliation":[{"name":"Institute of Virology, Medical Center\u2014University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bulli","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institute of Virology, University Hospital Heidelberg, Heidelberg, 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