{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:04:56Z","timestamp":1789088696303,"version":"build-2803163510"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"20","license":[{"start":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T00:00:00Z","timestamp":1224028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The majority of acute hepatitis C virus (HCV) infections progress to chronicity and progressive liver damage. Alpha interferon (IFN-\u03b1) antiviral therapy achieves the highest rate of success when IFN-\u03b1 is administered early during the acute phase, but the underlying mechanisms are unknown. We used a panel of major histocompatibility complex class I tetramers to monitor the phenotypic and functional signatures of HCV-specific T cells during acute HCV infection with different infection outcomes and during early IFN therapy. We demonstrate that spontaneous resolution correlates with the early development of polyfunctional (IFN-\u03b3- and IL-2-producing and CD107a\n            <jats:sup>+<\/jats:sup>\n            ) virus-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells. These polyfunctional T cells are distinguished by the expression of CD127 and Bcl-2 and represent a transitional memory T-cell subset that exhibits the phenotypic and functional signatures of both central and effector memory T cells. In contrast, HCV-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells in acute infections evolving to chronicity expressed low levels of CD127 and Bcl-2, exhibited diminished proliferation and cytokine production, and eventually disappeared from the periphery. Early therapeutic intervention with pegylated IFN-\u03b1 rescued polyfunctional memory T cells expressing high levels of CD127 and Bcl-2. These cells were detectable for up to 1 year following discontinuation of therapy. Our results suggest that the polyfunctionality of HCV-specific T cells can be predictive of the outcome of acute HCV infection and that early therapeutic intervention can reconstitute the pool of long-lived polyfunctional memory T cells.\n          <\/jats:p>","DOI":"10.1128\/jvi.01083-08","type":"journal-article","created":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T00:55:28Z","timestamp":1217465728000},"page":"10017-10031","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":120,"title":["Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8\n            <sup>+<\/sup>\n            Memory T Cells"],"prefix":"10.1128","volume":"82","author":[{"given":"Gamal","family":"Badr","sequence":"first","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l'Universite\u0301 de Montre\u0301al, CRCHUM, Ho\u0302pital St. Luc, Montre\u0301al, QC, Canada"},{"name":"Faculty 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