{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:26:09Z","timestamp":1791278769219,"version":"4.1.0"},"reference-count":58,"publisher":"American Society for Microbiology","issue":"15","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Previous studies have demonstrated that type I interferon (IFN-I) restricts West Nile virus (WNV) replication and pathogenesis in peripheral and central nervous system (CNS) tissues. However, the\n                    <jats:italic>in vivo<\/jats:italic>\n                    role of specific antiviral genes that are induced by IFN-I against WNV infection remains less well characterized. Here, using\n                    <jats:italic>Ifit2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, we defined the antiviral function of the interferon-stimulated gene (ISG)\n                    <jats:italic>Ifit2<\/jats:italic>\n                    in limiting infection and disease\n                    <jats:italic>in vivo<\/jats:italic>\n                    by a virulent North American strain of WNV. Compared to congenic wild-type controls,\n                    <jats:italic>Ifit2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice showed enhanced WNV infection in a tissue-restricted manner, with preferential replication in the CNS of animals lacking\n                    <jats:italic>Ifit2<\/jats:italic>\n                    . Virological analysis of cultured macrophages, dendritic cells, fibroblasts, cerebellar granule cell neurons, and cortical neurons revealed cell type-specific antiviral functions of Ifit2 against WNV. In comparison, small effects of Ifit2 were observed on the induction or magnitude of innate or adaptive immune responses. Our results suggest that Ifit2 restricts WNV infection and pathogenesis in different tissues in a cell type-specific manner.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01097-13","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T20:16:37Z","timestamp":1370463397000},"page":"8363-8371","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":80,"title":["A Role for Ifit2 in Restricting West Nile Virus Infection in the Brain"],"prefix":"10.1128","volume":"87","author":[{"given":"Hyelim","family":"Cho","sequence":"first","affiliation":[{"name":"Departments of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimmi","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganes C.","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Departments of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, 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