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It is generally believed that virus-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cell responses are required for the clearance of HBV. However, the relative contributions of genetic variation and innate immune responses to the induction of HBV-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cell responses are not fully understood. In this study, we discovered that different clearance rates between HBV clones after hydrodynamic transduction were associated with the magnitude of HBV-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cell responses and initial HB core antigen expression. Surprisingly, type I interferon signaling negatively regulated HBV-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cell responses by reducing early HBV antigen expression. These results show that the magnitude of the HBV-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cell response is regulated primarily by the initial antigen expression level.\n          <\/jats:p>","DOI":"10.1128\/jvi.01099-18","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T09:25:34Z","timestamp":1536830734000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Type I Interferon Signaling Prevents Hepatitis B Virus-Specific T Cell Responses by Reducing Antigen Expression"],"prefix":"10.1128","volume":"92","author":[{"given":"Keigo","family":"Kawashima","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan"},{"name":"Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, 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