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VZV is closely related to HSV-1, causes chickenpox during primary infection, and establishes life-long latency in ganglia, from where it can reactivate to cause herpes zoster (shingles). Unlike HSV-1, VZV only infects humans, and there are limited model systems; thus, little is known concerning how VZV maintains latency and why VZV reactivates. Through studying the link between immune cell cytotoxic functions, granzyme B, and viral gene products, an increased understanding of viral pathogenesis will be achieved.<\/jats:p>","DOI":"10.1128\/jvi.01140-19","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T09:45:13Z","timestamp":1566899113000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Granzyme B Cleaves Multiple Herpes Simplex Virus 1 and Varicella-Zoster Virus (VZV) Gene Products, and VZV ORF4 Inhibits Natural Killer Cell Cytotoxicity"],"prefix":"10.1128","volume":"93","author":[{"given":"Chelsea","family":"Gerada","sequence":"first","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-4204","authenticated-orcid":false,"given":"Megan","family":"Steain","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa Mollie","family":"Campbell","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0473-2789","authenticated-orcid":false,"given":"Brian","family":"McSharry","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Slobedman","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Abendroth","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-34127-9_1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/2042-4280-3-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3215"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.9.1459"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164164"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00149-2"},{"key":"e_1_3_3_8_2","first-page":"1802","volume-title":"Fields virology","author":"Pellett P","year":"2013","unstructured":"Pellett P, Roizman B. 2013. 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