{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:48:34Z","timestamp":1792496914981,"version":"4.5.0"},"reference-count":68,"publisher":"American Society for Microbiology","issue":"20","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100012226","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170146"],"award-info":[{"award-number":["32170146"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170140"],"award-info":[{"award-number":["32170140"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100108"],"award-info":[{"award-number":["32100108"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities","doi-asserted-by":"publisher","award":["2017TD-08"],"award-info":[{"award-number":["2017TD-08"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Department of Jilin Province","award":["20210101314JC"],"award-info":[{"award-number":["20210101314JC"]}]},{"name":"Key Laboratory of Molecular Virology, Jilin Province","award":["20102209"],"award-info":[{"award-number":["20102209"]}]},{"DOI":"10.13039\/501100017585","name":"First Hospital of Jilin University","doi-asserted-by":"publisher","award":["2020-CXQ-02"],"award-info":[{"award-number":["2020-CXQ-02"]}],"id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:p>Human immunodeficiency viruses are pathogens of AIDS that were first discovered almost 40\u2009years ago and continue to threaten human lives to date. While currently used anti-HIV drugs are sufficient to suppress viral loads in HIV-infected patients, both drug-resistant HIV strains and adverse side effects triggered by the long-term use of these drugs highlight the need to develop novel anti-HIV drugs targeting different viral proteins and\/or different steps in viral replication.<\/jats:p>","DOI":"10.1128\/jvi.01148-22","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T17:01:03Z","timestamp":1664989263000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Nef Suppresses LINE-1 Retrotransposition through Two Distinct Mechanisms"],"prefix":"10.1128","volume":"96","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Center of Infectious Diseases and Pathogen Biology, First Hospital of Jilin University, Changchun, Jilin, China"},{"name":"Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5833-1852","authenticated-orcid":true,"given":"Ke","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases and Pathogen Biology, First Hospital of Jilin University, Changchun, Jilin, China"},{"name":"Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases and Pathogen Biology, First Hospital of Jilin University, Changchun, Jilin, China"},{"name":"Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases and Pathogen Biology, First Hospital of Jilin University, Changchun, Jilin, China"},{"name":"Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases and Pathogen Biology, First Hospital of Jilin University, Changchun, Jilin, China"},{"name":"Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5848-8668","authenticated-orcid":true,"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases and Pathogen Biology, First Hospital of Jilin University, Changchun, Jilin, China"},{"name":"Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin, China"},{"name":"Key Laboratory of Organ Regeneration &amp; Transplantation of the Ministry of Education, First Hospital of Jilin University, Changchun, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.35.102401.091032"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-082509-141802"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00395.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi354"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1722352"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81997-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1223"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr245"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2326704"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35057062"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089670"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gni056"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2867-6-13"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1332"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906552106"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2236"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.08.019"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.02.009"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1941"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx178"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1489"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2018.05.015"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2021.1893640"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.01.089"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.07.009"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.02.007"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509417103"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008076107"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky688"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06553"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.03.001"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01610-21"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005252"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39795"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1996.7.10-1205"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.59.2.284-291.1986"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.6.1418"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.8.1557"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13100-016-0070-z"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15399"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15400"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.10.1697"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh698"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00232"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2997921"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(86)90219-9"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13100-022-00268-0"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1107"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt225"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.021"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02257-13"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/350508a0"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0396-338"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-5-84"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.10.002"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01465-16"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.1483"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.7.4283-4290.1996"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005367"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0421-x"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12769"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.597062"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0585-4"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0198-065"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.732775"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81998-4"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.012"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02199-12"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01148-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01148-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T13:07:15Z","timestamp":1666789635000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.01148-22"}},"subtitle":[],"editor":[{"given":"Viviana","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":68,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2022,10,26]]}},"alternative-id":["10.1128\/jvi.01148-22"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01148-22","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"2022-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01148-22"}}