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This additional layer of epigenetic regulation is also utilized by DNA viruses, including herpesviruses. Dynamic, spatial genomic organization often involves looping of chromatin anchored by host-encoded CCCTC-binding factor (CTCF) and other factors, which control crosstalk between promoters and enhancers. Herein, we review the contribution of CTCF-mediated looping in regulating transcription during herpesvirus infection, with a specific focus on the betaherpesvirus, human cytomegalovirus (HCMV).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/jvi.01148-24","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T13:01:04Z","timestamp":1725022864000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Loopy virus or controlled contortionist? 3D regulation of HCMV gene expression by CTCF-driven chromatin interactions"],"prefix":"10.1128","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-6701","authenticated-orcid":false,"given":"Ian J.","family":"Groves","sequence":"first","affiliation":[{"name":"Infection Biology Program, Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA"},{"name":"Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4943-3774","authenticated-orcid":false,"given":"Christine M.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Infection Biology Program, Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA"},{"name":"Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.12.032"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.33"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00498-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00710-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2022.101257"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.11.009"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2021.105103"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2024.110146"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/v15051088"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3454"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.179804.111"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00565-22"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02089-9"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27894-1"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00755-18"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00582-z"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00326-23:e0032623"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9110869"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00476"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00845-14"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001609"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2315860121"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202255146"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.09.023"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.254268"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317788111"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.237"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes13081383"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12101357"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08098"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005752"},{"key":"e_1_3_2_33_2","volume-title":"46th International Herpesvirus Workshop, Poster 419","author":"Maestri D","year":"2022","unstructured":"Maestri D, Caruso L, Alp S, Sobotka A, Tempera I. 2022. 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