{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:52:31Z","timestamp":1784890351671,"version":"3.55.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"20","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,9,29]]},"abstract":"<jats:p>\n            Members of the\n            <jats:italic>Pegivirus<\/jats:italic>\n            genus, family\n            <jats:italic>Flaviviridae<\/jats:italic>\n            , widely infect humans and other mammals, but are described as causing persistent infection and lacking pathogenicity. The efficiency of\n            <jats:italic>in vitro<\/jats:italic>\n            replication systems for pegivirus is poor, thus limiting investigation into viral replication steps. Because of that, the pathogenesis, cellular tropism, route of transmission, biology, and epidemiology of pegiviruses remain largely uncovered. Here, we report a phylogenetically distinct goose pegivirus (GPgV) that should be classified as a new species. GPgV proliferated in cell culture in a species- and cell-type-specific manner. Animal experiments show GPgV lymphotropism and promote goose parvovirus clinical manifestations. This study provides the first cell culture model for pegivirus, opening new possibilities for studies of pegivirus molecular biology. More importantly, our findings stand in contrast to the lack of identified pathogenicity of previously reported pegiviruses, which sheds lights on the pathobiology of pegivirus.\n          <\/jats:p>","DOI":"10.1128\/jvi.01150-20","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T13:10:06Z","timestamp":1596460206000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["The First Nonmammalian Pegivirus Demonstrates Efficient\n            <i>In Vitro<\/i>\n            Replication and High Lymphotropism"],"prefix":"10.1128","volume":"94","author":[{"given":"Zhen","family":"Wu","sequence":"first","affiliation":[{"name":"Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, Sichuan Province, 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