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We report that IFN-\u03b3 has more potent activity than IFN-\u03b1 against VZV. Findings from this comparative analysis show that the IFN-\u03b1\u2013IRF9 axis functions as a first line of defense to delay the onset of viral replication and spread, whereas the IFN-\u03b3\u2013IRF1 axis has the capacity to block the infectious process. Our findings underscore the importance of IRFs in IFN regulation of herpesvirus infection and account for the clinical experience of the initial control of VZV skin infection attributable to IFN-\u03b1 production, together with the requirement for induction of adaptive IFN-\u03b3-producing VZV-specific T cells to resolve the infection.<\/jats:p>","DOI":"10.1128\/jvi.01151-18","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T07:11:53Z","timestamp":1533712313000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["Distinctive Roles for Type I and Type II Interferons and Interferon Regulatory Factors in the Host Cell Defense against Varicella-Zoster Virus"],"prefix":"10.1128","volume":"92","author":[{"given":"Nandini","family":"Sen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Stanford University, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Panda","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Arvin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University, Stanford, California, USA"},{"name":"Department of Microbiology &amp; Immunology, Stanford University, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3215"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040634"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.3.422"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2010_31"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.778-809.2001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R700016200"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4161\/onci.22475"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1604"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.203"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00322-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.052"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004901"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198204013061301"},{"key":"e_1_3_3_15_2","first-page":"2151","article-title":"Association of reduced CD4 T cell responses specific to varicella zoster virus with high incidence of herpes zoster in patients with systemic lupus erythematosus","volume":"31","author":"Park HB","year":"2004","unstructured":"Park HB, Kim KC, Park JH, Kang TY, Lee HS, Kim TH, Jun JB, Bae SC, Yoo DH, Craft J, Jung S. 2004. 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