{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:57:35Z","timestamp":1791107855532,"version":"4.1.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T00:00:00Z","timestamp":1205539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>GB virus B (GBV-B) is a hepatotropic virus that is closely related to hepatitis C virus (HCV). GBV-B causes acute hepatitis in infected marmosets and tamarins and is therefore a useful small-animal model for the study of HCV. We investigated virus-specific T-cell responses in marmosets infected with GBV-B. Gamma interferon (IFN-\u03b3) enzyme-linked immunospot (ELISPOT) assay responses in the peripheral blood of two marmosets were assessed throughout the course of GBV-B infection. These T-cell responses were directed against the GBV-B nonstructural proteins 3 (NS3), 4A (NS4A), and 5B (NS5B), and their appearance was temporally associated with clearance of viremia. These marmosets were then rechallenged with GBV-B at least 3 months after clearance of the primary infection to determine if the animals were protected from reinfection. There was no detectable viremia following reinfection, although a sharp increase in T-cell responses against GBV-B proteins was observed. Epitope mapping of T-cell responses to GBV-B was performed with liver and blood samples from both marmosets after rechallenge with GBV-B. Three shared, immunodominant T-cell epitopes within NS3 were identified in animals with multiple common major histocompatibility complex class I alleles. IFN-\u03b3 ELISPOT responses were also detected in the livers of two marmosets that had resolved a primary GBV-B infection. These responses were high in frequency and were directed against epitopes within GBV-B NS3, NS4A, and NS5B proteins. These results indicate that virus-specific T-cell responses are detectable in the liver and blood of GBV-B-infected marmosets and that the clearance of GBV-B is associated with the appearance of these responses.<\/jats:p>","DOI":"10.1128\/jvi.01153-07","type":"journal-article","created":{"date-parts":[[2007,12,19]],"date-time":"2007-12-19T20:53:51Z","timestamp":1198097631000},"page":"3054-3060","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Virus-Specific T-Cell Immunity Correlates with Control of GB Virus B Infection in Marmosets"],"prefix":"10.1128","volume":"82","author":[{"given":"David J.","family":"Woollard","sequence":"first","affiliation":[{"name":"The Burnet Institute, G.P.O. Box 2284, Melbourne, Victoria, Australia"},{"name":"Department of Immunology, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Haqshenas","sequence":"additional","affiliation":[{"name":"The Burnet Institute, G.P.O. Box 2284, Melbourne, Victoria, Australia"},{"name":"Department of Microbiology, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Dong","sequence":"additional","affiliation":[{"name":"The Burnet Institute, G.P.O. Box 2284, Melbourne, Victoria, Australia"},{"name":"Department of Microbiology, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget F.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Kent","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Gowans","sequence":"additional","affiliation":[{"name":"The Burnet Institute, G.P.O. Box 2284, Melbourne, Victoria, Australia"},{"name":"Department of Microbiology, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11745"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24371"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.24.11764-11772.2000"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.4.2062-2071.2004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9941"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.9.4291-4301.2000"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.21162"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02076-06"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80044-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.12584-12595.2002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.16.7792"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1353"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200108)31:8<2388::AID-IMMU2388>3.0.CO;2-L"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088774"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82467-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5692"},{"key":"e_1_3_2_18_2","first-page":"327","volume":"242","year":"2000","unstructured":"Houghton, M. 2000. 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