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Previous work had found that MVA vectors should be designed to express stable protein in order to induce robust immunity by CD8\n                    <jats:sup>+<\/jats:sup>\n                    (cytotoxic) T cells. Here, we found that the primacy of stable antigen is not generalizable to all designs of MVA and may depend where a foreign antigen is inserted into the MVA genome. This unexpected finding suggests that there is an interaction between genome location and the best form of antigen for optimal T cell priming in MVA and thus possibly other vaccine vectors. It also highlights that our understanding of antigen presentation by even the best studied of vaccine vectors remains incomplete.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01154-19","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T08:38:36Z","timestamp":1564994316000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Modified Vaccinia Virus Ankara Can Induce Optimal CD8\n                    <sup>+<\/sup>\n                    T Cell Responses to Directly Primed Antigens Depending on Vaccine Design"],"prefix":"10.1128","volume":"93","author":[{"given":"Yik Chun","family":"Wong","sequence":"first","affiliation":[{"name":"John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Croft","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart A.","family":"Smith","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon C. 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