{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:36:17Z","timestamp":1792798577176,"version":"4.5.0"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"17","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"MHRD STARS, India","award":["STARS\/APR2019\/BS\/584\/FS"],"award-info":[{"award-number":["STARS\/APR2019\/BS\/584\/FS"]}]},{"name":"Department of Biotechnology, India","award":["BT\/PR14240\/Med\/29\/985\/2015"],"award-info":[{"award-number":["BT\/PR14240\/Med\/29\/985\/2015"]}],"id":[{"id":"https:\/\/ror.org\/03tjsyq23","id-type":"ROR","asserted-by":"crossref"}]},{"name":"University Grants Commission, India","award":["41-518\/2012[SR]"],"award-info":[{"award-number":["41-518\/2012[SR]"]}],"id":[{"id":"https:\/\/ror.org\/04p800546","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,8,17]]},"abstract":"<jats:p>\n                    Approximately 40% of the world\u2019s population is at risk of dengue virus infection. There is currently no specific drug or potential vaccine for these infections. Lack of complete understanding of the pathogenesis of the virus is one of the hurdles that must be overcome in developing antivirals for this virus infection. In the present study, we observed that the dengue virus-coded protease imports to the mitochondrial matrix, and our report is the first ever of a virus-coded protein, either animal or human, importing to the mitochondrial matrix. Our analysis indicates that the observed mitochondrial import is due to an inherited mitochondrial transport signal. We also show that matrix-localized GrpE protein homolog 1 (GrpEL1), a cochaperone of mitochondrial Hsp70 (mtHsp70), is also the substrate of dengue virus protease, as observed\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>ex vivo<\/jats:italic>\n                    in virus-infected cells and dengue virus-infected clinical samples. Hence, our studies reveal an essential aspect of the pathogenesis of dengue virus infections, which may aid in developing antidengue therapeutics.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01178-20","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T10:29:46Z","timestamp":1592908186000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Mitochondrial Import of Dengue Virus NS3 Protease and Cleavage of GrpEL1, a Cochaperone of Mitochondrial Hsp70"],"prefix":"10.1128","volume":"94","author":[{"given":"Chaitanya","family":"Gandikota","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fareed","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekha","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Maisnam","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ushodaya","family":"Mattam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Rathore","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katyayani","family":"Mallick","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arcy","family":"Billoria","sequence":"additional","affiliation":[{"name":"Lotus Children\u2019s Hospital, Lakdikapul, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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