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The establishment of latent infection, which is lifelong and can precede tumor development by years, requires the concerted actions of nearly a dozen EBV proteins and numerous small non-protein-coding RNAs. Elucidating how these EBV products contribute to latency is crucial for understanding EBV\u2019s role in specific malignancies and, ultimately, for clinical intervention. Historically, EBV genes that contribute to virus replication have been excluded from consideration of a role in latency, primarily because of the general incompatibility between virus production and cell survival. However, here, we provide evidence that the genetic locus containing one such gene,\n            <jats:italic>BHLF1<\/jats:italic>\n            , indeed contributes to key aspects of EBV latency, including its ability to promote the continuous growth of B lymphocytes, thus providing significant new insight into EBV biology and oncogenic potential.\n          <\/jats:p>","DOI":"10.1128\/jvi.01215-20","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T13:41:11Z","timestamp":1593006071000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["The BHLF1 Locus of Epstein-Barr Virus Contributes to Viral Latency and B-Cell Immortalization"],"prefix":"10.1128","volume":"94","author":[{"given":"Kristen D.","family":"Yetming","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA"},{"name":"Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena N.","family":"Lupey-Green","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA"},{"name":"Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei","family":"Biryukov","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA"},{"name":"Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0090-5710","authenticated-orcid":false,"given":"David J.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA"},{"name":"Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elessa M.","family":"Marendy","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA"},{"name":"Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JJ L.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Pharmacology, University of California\u2014San Francisco, San Francisco, California, USA"},{"name":"Gladstone Institute of Virology and Immunology, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2610-492X","authenticated-orcid":false,"given":"Jeffery T.","family":"Sample","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA"},{"name":"Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22822-8_8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9411"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.1.623-627.1996"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.8.5039-5047.1995"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.66.1.122-131.1992"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030404"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01416-06"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911948107"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.13993-14003.2005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01512-10"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2173142"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.439"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002704"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.6.2390.2390_2390_2397"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.12.7406-7413.1993"},{"key":"e_1_3_2_17_2","first-page":"1711","article-title":"The Epstein-Barr virus encoded cytokine viral interleukin-10 enhances transformation of human B lymphocytes","volume":"11","author":"Stuart AD","year":"1995","unstructured":"Stuart AD, Stewart JP, Arrand JR, Mackett M. 1995. 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