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As there are neither effective preventive measures nor approved treatment options available, there is an urgent need to identify antiviral drugs against FIPV. Our FCoV replicon system provides a valuable tool for drug discovery\n            <jats:italic>in vitro<\/jats:italic>\n            . Due to the lack of cell culture systems for serotype I FCoVs (the serotype most prevalent in the feline population) (2), a different system is needed to study these viruses. A viral replicon system is a valuable tool for studying FCoVs. Overall, our results demonstrate the utility of the serotype I feline coronavirus replicon system for antiviral screening as well as to study this virus in general. We propose several compounds representing promising candidates for future clinical trials and ultimately with the potential to save cats suffering from FIP.\n          <\/jats:p>","DOI":"10.1128\/jvi.01216-23","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T13:45:29Z","timestamp":1705585529000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["An RNA replicon system to investigate promising inhibitors of feline coronavirus"],"prefix":"10.1128","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6158-7074","authenticated-orcid":false,"given":"Kimberly","family":"Schmied","sequence":"first","affiliation":[{"name":"Institute of Virology and Immunology (IVI), Bern and Mittelh\u00e4usern, Switzerland"},{"name":"Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, 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