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In this study, we demonstrate that X4-tropic latent HIV-1 is preferentially enriched in pTFH cells, which also accurately reflects the viral tropism shift. The ratio of X4-tropic proviruses in pTFH cells but not in other memory CD4\n            <jats:sup>+<\/jats:sup>\n            T cell subsets is inversely and closely correlated with blood CD4\n            <jats:sup>+<\/jats:sup>\n            T cell counts and CD4\n            <jats:sup>+<\/jats:sup>\n            T cell recovery rates with cART. Our data suggest that the ratio of X4-tropic provirus in peripheral TFH cells can be easily measured and reflects disease progression and treatment outcomes during cART.\n          <\/jats:p>","DOI":"10.1128\/jvi.01219-19","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T12:07:46Z","timestamp":1572523666000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["X4-Tropic Latent HIV-1 Is Enriched in Peripheral Follicular Helper T Cells and Is Correlated with Disease Progression"],"prefix":"10.1128","volume":"94","author":[{"given":"Fei","family":"Yu","sequence":"first","affiliation":[{"name":"Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 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