{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:20:12Z","timestamp":1790403612904,"version":"4.1.0"},"reference-count":72,"publisher":"American Society for Microbiology","issue":"23","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2019A1515011336"],"award-info":[{"award-number":["2019A1515011336"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2020A1515010570"],"award-info":[{"award-number":["2020A1515010570"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2020A1515010870"],"award-info":[{"award-number":["2020A1515010870"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471935"],"award-info":[{"award-number":["81471935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Department of Science and Technology of Guangdong Province","doi-asserted-by":"crossref","award":["2018A050506029"],"award-info":[{"award-number":["2018A050506029"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970887"],"award-info":[{"award-number":["31970887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,11,9]]},"abstract":"<jats:p>\n            Zika virus (ZIKV) has been linked to serious neurologic disorders and causes widespread concern in the field of global public health. Inositol requiring enzyme 1\u03b1 (IRE1\u03b1) is an ER-related transmembrane protein that mediates unfolded protein response (UPR) pathway. Here, we revealed that IRE1\u03b1 is a proviral factor for ZIKV replication both in culture cells and mice model, which relies on its kinase and RNase activities. Importantly, we further provided evidence that upon ZIKV infection, IRE1\u03b1 is activated and splices\n            <jats:italic>XBP1<\/jats:italic>\n            mRNA which enhances the expression of monounsaturated fatty acids rate-limiting enzyme stearoyl coenzyme A (stearoyl-CoA) desaturase 1 (SCD1) and subsequent lipid droplet production. Our data uncover a novel mechanism of IRE1\u03b1 proviral effect by modulating lipid metabolism, providing the first evidence of a close relationship between IRE1\u03b1-mediated UPR, lipid metabolism, and ZIKV replication and indicating IRE1\u03b1 inhibitors as potentially effective anti-ZIKV agents.\n          <\/jats:p>","DOI":"10.1128\/jvi.01229-20","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T17:25:28Z","timestamp":1600709128000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Inositol-Requiring Enzyme 1\u03b1 Promotes Zika Virus Infection through Regulation of Stearoyl Coenzyme A Desaturase 1-Mediated Lipid Metabolism"],"prefix":"10.1128","volume":"94","author":[{"given":"Yanxia","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanshi","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiting","family":"Huo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cancan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shili","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocao","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixin","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3863-7210","authenticated-orcid":false,"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11663-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00496"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.03.010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10050233"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-100114-055007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1890"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00879-06"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.222703"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02050-10"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000792"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312144200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.017"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5453.664"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.992302"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01453-06"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00001.2011"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.170"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200903014"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129631"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1311-5"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.11.005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0038-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/v12030278"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0446-y"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1197142"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/415092a"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(01)00611-0"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3mb70234k"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.115.100917"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115623109"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95864"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.01.001"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700737"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.03.002"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007261"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409778111"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep04549"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01678-14"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2016.09.005"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01276"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2017.05.010"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2009.04.002"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.023"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2018.08.016"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/v9070165"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10010049"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.057265-0"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00526"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.02.019"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18909-3"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.259085"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01151-07"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01951"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02286"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.17420111"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061009-102430"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00045-14"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.12.012"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12688"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000632"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-8-1913"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2238"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000035"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.005"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82898-0"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00767.x"},{"key":"e_1_3_2_68_2","first-page":"150","article-title":"Understanding the structure and function of the capsid protein of Zika, West-Nile and Dengue viruses, namely their ability to interact with host lipid systems","volume":"26","author":"Martins A","year":"2017","unstructured":"Martins A, Martins I, Faustino A, Nascimento A, Carvalho F, Santos N. 2017. Understanding the structure and function of the capsid protein of Zika, West-Nile and Dengue viruses, namely their ability to interact with host lipid systems. Protein Sci 26:150.","journal-title":"Protein Sci"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.02.006"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01306-18"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.139626"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2019.01.019"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-017-0382-1"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01229-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01229-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T14:59:20Z","timestamp":1646492360000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01229-20"}},"subtitle":[],"editor":[{"given":"Stacey","family":"Schultz-Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,9]]},"references-count":72,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2020,11,9]]}},"alternative-id":["10.1128\/JVI.01229-20"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01229-20","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,9]]},"assertion":[{"value":"2020-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01229-20"}}