{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:18:35Z","timestamp":1777519115767,"version":"3.51.4"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001663","name":"Volkswagen Foundation","doi-asserted-by":"publisher","award":["A112662"],"award-info":[{"award-number":["A112662"]}],"id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2021,1,13]]},"abstract":"<jats:p>\n            Marek\u2019s disease virus (MDV) is a highly oncogenic alphaherpesvirus that infects chickens and causes losses in the poultry industry of up to $2 billion per year. The virus is also widely used as a model to study alphaherpesvirus pathogenesis and virus-induced tumor development in a natural host. MDV and most other herpesviruses harbor direct or inverted repeats regions in their genome. However, the role of these sequence duplications in MDV remains elusive and has never been investigated in a natural virus-host model for any herpesvirus. Here, we demonstrate that both copies of the repeats are needed for efficient MDV replication and pathogenesis\n            <jats:italic>in vivo<\/jats:italic>\n            , while replication was not affected in cell culture. With this, we further dissect herpesvirus genome biology and the role of repeat regions in Marek\u2019s disease virus replication and pathogenesis.\n          <\/jats:p>","DOI":"10.1128\/jvi.01256-20","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T13:29:51Z","timestamp":1603718991000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Marek\u2019s Disease Virus Requires Both Copies of the Inverted Repeat Regions for Efficient\n            <i>In Vivo<\/i>\n            Replication and Pathogenesis"],"prefix":"10.1128","volume":"95","author":[{"given":"Tereza","family":"Vychodil","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andel\u00e9 M.","family":"Conradie","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Trimpert","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Aswad","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0698-5395","authenticated-orcid":false,"given":"Luca D.","family":"Bertzbach","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-2695","authenticated-orcid":false,"given":"Benedikt B.","family":"Kaufer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"2479","volume-title":"Fields virology","author":"Pellet PE","year":"2001","unstructured":"Pellet PE, Roizman B. 2001. The family Herpesviridae: a brief introduction, p 2479\u20132499. In Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (ed), Fields virology, 4th ed. 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Cell-culture methods, p 223\u2013234. In Swayne D, Glisson JR, Jackwood MW, Pearson JE, Reed WM (ed), A laboratory manual for the isolation and identification of avian pathogens, 4th ed. 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