{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:44:40Z","timestamp":1788561880273,"version":"build-2803163510"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"20","license":[{"start":{"date-parts":[[2006,10,15]],"date-time":"2006-10-15T00:00:00Z","timestamp":1160870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2006,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Cultures derived from the cerebral cortices and hippocampi of 17-day-old mouse fetuses infected with the CVS strain of rabies virus showed loss of trypan blue exclusion, morphological apoptotic features, and activated caspase 3 expression, indicating apoptosis. The NMDA (\n            <jats:italic>N<\/jats:italic>\n            -methyl-\n            <jats:sc>d<\/jats:sc>\n            -aspartate acid) antagonists ketamine (125 \u03bcM) and MK-801 (60 \u03bcM) were found to have no significant neuroprotective effect on CVS-infected neurons, while the caspase inhibitor Ac-Asp-Glu-Val aspartic acid aldehyde (25 \u03bcM) exerted a marked neuroprotective effect. Glutamate-stimulated increases in levels of intracellular calcium were reduced in CVS-infected hippocampal neurons. Ketamine (120 mg\/kg of body weight\/day intraperitoneally) given to CVS-infected adult mice produced no beneficial effects. We have found no supportive evidence that excitotoxicity plays an important role in rabies virus infection.\n          <\/jats:p>","DOI":"10.1128\/jvi.01272-06","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T22:19:39Z","timestamp":1159395579000},"page":"10270-10273","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["Rabies Virus Infection of Primary Neuronal Cultures and Adult Mice: Failure To Demonstrate Evidence of Excitotoxicity"],"prefix":"10.1128","volume":"80","author":[{"given":"Simon C.","family":"Weli","sequence":"first","affiliation":[{"name":"Departments of Medicine (Neurology)"},{"name":"Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney A.","family":"Scott","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology"},{"name":"Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Ward","sequence":"additional","affiliation":[{"name":"Physiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Departments of Medicine (Neurology)"},{"name":"Microbiology and Immunology"},{"name":"Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00297-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1991.tb00812.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490350513"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-02-00357.1987"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2002-04.2004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/13550280590900445"},{"key":"e_1_3_2_8_2","unstructured":"J. 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