{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:25:40Z","timestamp":1787505940886,"version":"build-2736575974"},"reference-count":72,"publisher":"American Society for Microbiology","issue":"23","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["8P20GM103427"],"award-info":[{"award-number":["8P20GM103427"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Enterovirus infections are responsible for human diseases, including myocarditis, pancreatitis, acute flaccid paralysis, and poliomyelitis. The virulence of these viruses depends on efficient recognition of the RNA genome by a large family of host proteins and protein synthesis factors, which in turn relies on the three-dimensional folding of the first 750 nucleotides of the molecule. Structural information about this region of the genome, called the 5\u2032 untranslated region (5\u2032 UTR), is needed to assist in the process of vaccine and antiviral development. This work presents a model for the structure of the enteroviral 5\u2032 UTR. The model includes an RNA element called an intrinsically disordered RNA region (IDRR). Intrinsically disordered proteins (IDPs) are well known, but correlates in RNA have not been proposed. The proposed IDRR is a 20-nucleotide region, long known for its functional importance, where structural flexibility helps explain recognition by factors controlling multiple functional states.<\/jats:p>","DOI":"10.1128\/jvi.01288-19","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T12:06:31Z","timestamp":1568721991000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Structure of the 5\u2032 Untranslated Region of Enteroviral Genomic RNA"],"prefix":"10.1128","volume":"93","author":[{"given":"Bejan","family":"Mahmud","sequence":"first","affiliation":[{"name":"Biology Department, University of Nebraska at Omaha, Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Horn","sequence":"additional","affiliation":[{"name":"Biology Department, University of Nebraska at Omaha, Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Tapprich","sequence":"additional","affiliation":[{"name":"Biology Department, University of Nebraska at Omaha, Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx932"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0005-4"},{"key":"e_1_3_3_4_2","first-page":"490","volume-title":"Fields virology","author":"Pallansch MA","year":"2013","unstructured":"Pallansch MA, Oberste MS, Whitton JL. 2013. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses, p 490\u2013530. In Knipe DM, Howley PM (ed), Fields virology. Lippincott Williams & Wilkins, Philadelphia, PA."},{"key":"e_1_3_3_5_2","first-page":"454","volume-title":"Fields virology","author":"Racaniello VR","year":"2013","unstructured":"Racaniello VR. 2013. Picornaviridae: the viruses and their replication, p 454\u2013489. In Knipe DM, Howley PM (ed), Fields virology, 6th ed. Lippincott Williams & Wilkins, Philadelphia, PA.","edition":"6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2015.04.008"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01327-06"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.01.010"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.01.013"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.07.039"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(90)91476-n"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200009)62:1<70::AID-JMV11>3.0.CO;2-R"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(85)90001-5"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/10446670410001670427"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(72)90070-6"},{"key":"e_1_3_3_16_2","first-page":"395","article-title":"Coxsackievirus B3-induced acute pancreatitis: analysis of histopathological and viral parameters in a mouse model","volume":"70","author":"Vuorinen T","year":"1989","unstructured":"Vuorinen T, Kallajoki M, Hyypia T, Vainionpaa R. 1989. Coxsackievirus B3-induced acute pancreatitis: analysis of histopathological and viral parameters in a mouse model. Br J Exp Pathol 70:395\u2013403.","journal-title":"Br J Exp Pathol"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.5.3986-3991.1997"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/374877"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.10.4787-4794.2000"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027082"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku706"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.7.4384-4391.1994"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.3.1393-1402.2004"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.22.10696-10708.2001"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.6.1439"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000936"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2015.01.012"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(89)90261-1"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-1702(97)00096-8"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(88)90656-3"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.249"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja043822v"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx815"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000468766"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.11.6194-6204.1991"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1588"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2016.01.030"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1166808"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.0048"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.6.3658-3667.1995"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00141"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.12.038"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.14.6472-6481.2001"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80424-0"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01560-13"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.2.847-862.1989"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.12.7461-7471.1993"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.11.5886-5894.1991"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900153106"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-006-0155-3"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.62.12.4486-4492.1988"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1770"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(87)90435-1"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.14235-14243.2005"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.3.1467-1474.1996"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.061945.117"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2010.06.007"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-070816-034125"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1643609"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1057"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02629"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00516-07"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4066"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.5.2219-2226.2000"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201386124"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.03.012"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.003"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.036"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11504"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04948.x"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780471729259.mc15h03s30"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-129"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.75"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01288-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01288-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T09:51:27Z","timestamp":1646473887000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01288-19"}},"subtitle":[],"editor":[{"given":"Susana","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":72,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1128\/JVI.01288-19"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01288-19","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01288-19"}}