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The so-called \u201cextended\n                      <jats:italic toggle=\"yes\">Asfarviridae<\/jats:italic>\n                      \u201d\u2014 such as African swine fever virus, faustovirus, kaumoebavirus, pacmanvirus, and AbALV\u2014has long puzzled taxonomists. By integrating comparative genomics, pangenomics, and phylogenomics, we show these lineages are deeply divergent, forming multiple families rather than one. This work underscores the huge unexplored diversity of giant viruses and demonstrates the value of integrative genomic analyses for proper taxonomic delineation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/jvi.01337-25","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T14:04:38Z","timestamp":1763042678000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Integrative genomic analyses support the division of the extended\n                    <i>Asfarviridae<\/i>\n                    clade into multiple viral families"],"prefix":"10.1128","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-5739","authenticated-orcid":true,"given":"Thiago","family":"Mendon\u00e7a-Santos","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0176yjw32","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate Program in Bioinformatics, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG)","place":["Belo Horizonte, Brazil"]},{"id":[{"id":"https:\/\/ror.org\/04jhswv08","id-type":"ROR","asserted-by":"publisher"}],"name":"Laborat\u00f3rio de Medicina e Sa\u00fade P\u00fablica de Precis\u00e3o (MeSP2 ), Instituto Gon\u00e7alo Moniz (IGM), Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ)","place":["Salvador, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9420-1791","authenticated-orcid":true,"given":"J\u00f4natas","family":"Abrah\u00e3o","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0176yjw32","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology, Federal University of Minas Gerais (UFMG)","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-4476","authenticated-orcid":true,"given":"Luiz-Eduardo","family":"Del-Bem","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0176yjw32","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate Program in Bioinformatics, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG)","place":["Belo Horizonte, Brazil"]},{"name":"Department of Genetics, Luiz de Queiroz College of Agriculture (ESALQ), University of S\u00e3o Paulo (USP)","place":["Piracicaba, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081867"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1101485"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00115-15"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/v8110278"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00212-17"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61492-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.12.2607"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbinf.2023.1322477"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-015-0517-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf436"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026334"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu300"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4285"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msac215"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001430"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002195"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1293"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2067-0_16"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","unstructured":"Rodriguez-R LM Konstantinidis KT. 2016 The enveomics collection: a toolbox for specialized analyses of microbial genomes and metagenomes. 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