{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:57:31Z","timestamp":1777622251514,"version":"3.51.4"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T00:00:00Z","timestamp":1168819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2007,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The differentiation and functional status of virus-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells is significantly influenced by specific and ongoing antigen recognition. Importantly, the expression profiles of the interleukin-7 receptor alpha chain (CD127) and the killer cell lectin-like receptor G1 (KLRG1) have been shown to be differentially influenced by repetitive T-cell receptor interactions. Indeed, antigen-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells targeting persistent viruses (e.g., human immunodeficiency virus and Epstein-Barr virus) have been shown to have low CD127 and high KLRG1 expressions, while CD8\n            <jats:sup>+<\/jats:sup>\n            T cells targeting resolved viral antigens (e.g., FLU) typically display high CD127 and low KLRG1 expressions. Here, we analyzed the surface phenotype and function of hepatitis C virus (HCV)-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells. Surprisingly, despite viral persistence, we found that a large fraction of peripheral HCV-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells were CD127\n            <jats:sup>+<\/jats:sup>\n            and KLRG1\n            <jats:sup>\u2212<\/jats:sup>\n            and had good proliferative capacities, thus resembling memory cells that usually develop following acute resolving infection. Intrahepatic virus-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells displayed significantly reduced levels of CD127 expression but similar levels of KLRG1 expression compared to the peripheral blood. These results extend previous studies that demonstrated central memory (CCR7\n            <jats:sup>+<\/jats:sup>\n            ) and early-differentiated phenotypes of HCV-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells and suggest that insufficient stimulation of virus-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells by viral antigen may be responsible for this alteration in HCV-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T-cell differentiation during chronic HCV infection.\n          <\/jats:p>","DOI":"10.1128\/jvi.01354-06","type":"journal-article","created":{"date-parts":[[2006,12,27]],"date-time":"2006-12-27T23:52:56Z","timestamp":1167263576000},"page":"945-953","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":91,"title":["Analysis of CD127 and KLRG1 Expression on Hepatitis C Virus-Specific CD8\n            <sup>+<\/sup>\n            T Cells Reveals the Existence of Different Memory T-Cell Subsets in the Peripheral Blood and Liver"],"prefix":"10.1128","volume":"81","author":[{"given":"Bertram","family":"Bengsch","sequence":"first","affiliation":[{"name":"Department of Medicine II"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Christian","family":"Spangenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine II"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Kersting","sequence":"additional","affiliation":[{"name":"Department of Medicine II"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Neumann-Haefelin","sequence":"additional","affiliation":[{"name":"Department of Medicine II"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Panther","sequence":"additional","affiliation":[{"name":"Department of Medicine II"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"von Weizsa\u0308cker","sequence":"additional","affiliation":[{"name":"Department of Medicine II"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert E.","family":"Blum","sequence":"additional","affiliation":[{"name":"Department of Medicine II"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute of Medical Microbiology, University of Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Thimme","sequence":"additional","affiliation":[{"name":"Department of Medicine 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