{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:15:25Z","timestamp":1791321325446,"version":"4.3.1"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2010,2,15]],"date-time":"2010-02-15T00:00:00Z","timestamp":1266192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2010,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The retinoic acid-inducible gene I product (RIG-I) is a cellular sensor of RNA virus infection that regulates the cellular beta interferon (IFN-\u03b2) response. The nucleoproteins (NP) of arenaviruses are reported to antagonize the IFN response by inhibiting interferon regulatory factor 3 (IRF-3). Here, we demonstrate that the Z proteins of four New World (NW) arenaviruses, Guanarito virus (GTOV), Junin virus (JUNV), Machupo virus (MAVC), and Sabia virus (SABV), bind to RIG-I, resulting in downregulation of the IFN-\u03b2 response. We show that expression of the four NW arenavirus Z proteins inhibits IFN-\u03b2 mRNA induction in A549 cells in response to RNA bearing 5\u2032 phosphates (5\u2032pppRNA). NW arenavirus Z proteins interact with RIG-I in coimmunoprecipitation studies and colocalize with RIG-I. Furthermore, expression of Z proteins interferes with the interaction between RIG-I and MAVS. Z expression also impedes the nuclear factor kappa light chain enhancer of activated B cells (NF-\u03baB) and IRF-3 activation. Our results indicate that NW arenavirus Z proteins, but not Z protein of the Old World (OW) arenavirus lymphocytic choriomeningitis virus (LCMV) or Lassa virus, bind to RIG-I and inhibit downstream activation of the RIG-I signaling pathway, preventing the transcriptional induction of IFN-\u03b2.<\/jats:p>","DOI":"10.1128\/jvi.01362-09","type":"journal-article","created":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T01:55:14Z","timestamp":1260410114000},"page":"1785-1791","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":143,"title":["Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction"],"prefix":"10.1128","volume":"84","author":[{"given":"Lina","family":"Fan","sequence":"first","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Briese","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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