{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:43:00Z","timestamp":1792050180763,"version":"4.4.0"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"European Research Council","award":["Starting grant 802780"],"award-info":[{"award-number":["Starting grant 802780"]}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Meervoud 836.12.012"],"award-info":[{"award-number":["Meervoud 836.12.012"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001722","name":"Koninklijke Nederlandse Akademie van Wetenschappen","doi-asserted-by":"publisher","award":["Beijerinck Premium"],"award-info":[{"award-number":["Beijerinck Premium"]}],"id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,1,6]]},"abstract":"<jats:p>Infectious bronchitis virus is the causative agent of infectious bronchitis in chickens. Upon infection of chicken flocks, the poultry industry faces substantial economic losses by diminished egg quality and increased morbidity and mortality of infected animals. While all IBV strains infect the chicken respiratory tract via the ciliated epithelial layer of the trachea, some strains can also replicate in the kidneys, dividing IBV into the following two pathotypes: nonnephropathogenic (example, IBV-M41) and nephropathogenic viruses (including IBV-QX). Here, we set out to identify the determinants for the extended nephropathogenic tropism of IBV-QX. Our data reveal that each pathotype makes use of a different sialylated glycan ligand, with binding sites on opposite sides of the attachment protein. This knowledge should facilitate the design of antivirals to prevent coronavirus infections in the field.<\/jats:p>","DOI":"10.1128\/jvi.01363-19","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T13:51:15Z","timestamp":1572616275000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Three Amino Acid Changes in Avian Coronavirus Spike Protein Allow Binding to Kidney Tissue"],"prefix":"10.1128","volume":"94","author":[{"given":"Kim M.","family":"Bouwman","sequence":"first","affiliation":[{"name":"Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alinda J.","family":"Berends","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Cipollo","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique H.","family":"Verheije","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2307\/1593047"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2017.1387231"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.02.015"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1051\/vetres\/2009054"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079450802632049"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007384"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252317000044"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.162.3.99"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.04.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079459708419246"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1637\/7983-041307.1"},{"key":"e_1_3_2_13_2","first-page":"1","article-title":"Isolation and identification of glandular stomach type IBV (QX IBV) in chickens","volume":"15","author":"Yudong W","year":"1998","unstructured":"Yudong W, Yonglin W, Zichun Z, Genche F, Yihai J, Xiange L, Jiang D, Shushuang W. 1998. Isolation and identification of glandular stomach type IBV (QX IBV) in chickens. Chinese J Anim Quarantine 15:1\u20133.","journal-title":"Chinese J Anim Quarantine"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2307\/1592981"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/0307945042000220697"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.09.018"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2016.08.030"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.007532"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.16.9084-9089.2003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05112-11"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007009"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2013.09.006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(86)90022-5"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20853"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128893"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00067-19"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00745-15"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.8.5634-5637.1996"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00430-15"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.02.008"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.11.004"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.05.048"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90135-7"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1993.1079"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(90)90396-q"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01363-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01363-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:05:08Z","timestamp":1646492708000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01363-19"}},"subtitle":[],"editor":[{"given":"Tom","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,6]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1,6]]}},"alternative-id":["10.1128\/JVI.01363-19"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01363-19","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,6]]},"assertion":[{"value":"2019-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01363-19"}}