{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:29:06Z","timestamp":1792114146857,"version":"4.4.0"},"reference-count":90,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/AuthorWarrantyLicense.v1"},{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:p>\n                    Pathogenic henipaviruses such as Nipah virus (NiV) and Hendra virus (HeV) cause respiratory symptoms, with severe cases resulting in encephalitis, seizures, and coma. The work described here shows that the NiV and HeV fusion (F) proteins share common structural features with the F protein from an emerging henipavirus\n                    <jats:italic>,<\/jats:italic>\n                    Langya virus (LayV). Sequence alignment alone was sufficient to predict which known prefusion-stabilizing amino acid substitutions from NiV F would stabilize the prefusion conformations of HeV F and LayV F. This work also reveals an unexpected oligomeric interface shared by prefusion HeV F and NiV F. Together, these advances lay a foundation for future antigen design targeting henipavirus F proteins. In this way, Nipah virus can serve as a prototypical pathogen for the development of protective vaccines and monoclonal antibodies to prepare for potential henipavirus outbreaks.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01372-23","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T09:01:00Z","timestamp":1705050060000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Prefusion stabilization of the Hendra and Langya virus F proteins"],"prefix":"10.1128","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-8951","authenticated-orcid":true,"given":"Patrick O.","family":"Byrne","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth G.","family":"Blade","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Ambrozak","sequence":"additional","affiliation":[{"name":"Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9778-5987","authenticated-orcid":true,"given":"Ajit R.","family":"Ramamohan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barney S.","family":"Graham","sequence":"additional","affiliation":[{"name":"Morehouse School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-4728","authenticated-orcid":false,"given":"Rebecca J.","family":"Loomis","sequence":"additional","affiliation":[{"name":"Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3991-542X","authenticated-orcid":true,"given":"Jason S.","family":"McLellan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5470.1432"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04299-3"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.20506\/rst.19.1.1202"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1705.100968"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004273421701"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy612"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2018.01130"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1202.051247"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2102.141433"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1307.061128"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1110.050513"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1012.040701"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/647951"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1508.081237"},{"key":"e_1_3_4_16_2","first-page":"117","article-title":"Nipah virus - the rising epidemic: a review","volume":"27","author":"Ochani RK","year":"2019","unstructured":"Ochani RK, Batra S, Shaikh A, Asad A. 2019. Nipah virus - the rising epidemic: a review. Infez Med 27:117\u2013127.","journal-title":"Infez Med"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-017-0233-9"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1602.090780"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.07.011"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.12.003"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1863-2378.2012.01501.x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2309.161922"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1012.040452"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01875-17"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1386-6532(02)00268-8"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(01)01384-3"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2012_208"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2017.12.024"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0703.010312"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2202705"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2022.101292"},{"key":"e_1_3_4_32_2","first-page":"1340","volume-title":"Fundamental Virology","author":"Lamb RA","year":"1996","unstructured":"Lamb RA, Kolakofsky D. 1996. Paramyxoviridae: the viruses and their replication, p 1340. In Fields BN, Knipe DM, Howley PM (ed), Fundamental Virology, 3rd ed. Lippincott-Raven. xv, Philadelphia.","edition":"3"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504887102"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2009.02.025"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00842"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.772864"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.06.015"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2003.131159"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4020280"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/avj.12694"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.2.834-840.2004"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-019-0112-x"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-019-0112-x"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02308-14"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.10.012"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2506.181620"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-353"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis699"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00263-06"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058414"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002901"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000642"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1086\/528801"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.2.891-899.2006"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01318-12"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-019-0308-9"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-021-00584-8"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac296"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-2836(63)80023-6"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04322"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","unstructured":"Byrne PO Fisher BE Ambrozak DR Blade EG Tsybovsky Y Graham BS McLellan JS Loomis RJ. 2023. Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein. Nature Communications. doi:10.1038\/s41467-023-36995-y","DOI":"10.1038\/s41467-023-36995-y"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2622-0"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1269"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005322"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.17.6258"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.26.1.373"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17200"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.6.1335"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9143"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01708-9"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7260"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1707304114"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.025"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.17.8875-8889.2002"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","unstructured":"Wrapp D Mu Z Thakur B Janowska K Ajayi O Barr M Parks R Hahn BH Acharya P Saunders KO Haynes BF. 2023. Structure-based stabilization of SOSIP Env enhances recombinant ectodomain durability and yield. Journal of Virology. doi:10.1128\/jvi.01673-22","DOI":"10.1128\/jvi.01673-22"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2237415"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1811980115"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1243283"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd0826"},{"key":"e_1_3_4_80_2","unstructured":"KwongP Joyce M ZhangB YangY CollinsP BuchholzU CortiD LanzavecchiaA Stewart JonesG. 2019 issued . https:\/\/patents.google.com\/patent\/US11027007B2."},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39278-8"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00433-23"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1101\/2021.10.13.464285"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02393-14"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00693-09"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4169"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1523303113"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798318002425"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798319011471"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3235"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01372-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01372-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T09:16:33Z","timestamp":1708420593000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.01372-23"}},"subtitle":[],"editor":[{"given":"Christiane E.","family":"Wobus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":90,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,20]]}},"alternative-id":["10.1128\/jvi.01372-23"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01372-23","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,20]]},"assertion":[{"value":"2023-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01372-23"}}