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We have studied HIV controllers who suddenly lose this ability and present with high\n            <jats:italic>in vivo<\/jats:italic>\n            viral replication and decays in their CD4\n            <jats:sup>+<\/jats:sup>\n            T-cell counts to identify potential immune and virological factors that were responsible for initial virus control. We identify\n            <jats:italic>in vitro<\/jats:italic>\n            -determined reductions in the ability of CD8 T cells to suppress viral control and the presence of PD-1-expressing CD8\n            <jats:sup>+<\/jats:sup>\n            T cells with a naive immune phenotype as potential predictors of\n            <jats:italic>in vivo<\/jats:italic>\n            loss of virus control. The findings could be important for the clinical management of HIV controller individuals, and it may offer an important tool to anticipate viral rebound in individuals in clinical studies that include combination antiretroviral therapy (cART) treatment interruptions and which, if not treated quickly, could pose a significant risk to the trial participants.\n          <\/jats:p>","DOI":"10.1128\/jvi.01436-18","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T12:03:05Z","timestamp":1543320185000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Mechanisms of Abrupt Loss of Virus Control in a Cohort of Previous HIV Controllers"],"prefix":"10.1128","volume":"93","author":[{"given":"Miriam","family":"Ros\u00e1s-Umbert","sequence":"first","affiliation":[{"name":"IrsiCaixa AIDS Research Institute\u2013HIVACAT, Hospital Universitari Germans Trias i Pujol, Badalona, 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