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We have previously shown that an excess of proliferation occurs in lymphoid tissues and that the peripheral blood population is prone to increased cell death. To further understand the mechanisms involved, we evaluated the physiological role of the spleen in this accelerated turnover. To this end, B lymphocytes were labeled in vivo using a fluorescent marker (carboxyfluorescein diacetate succinimidyl ester), and the cell kinetic parameters (proliferation and death rates) of animals before and after splenectomy were compared. We show that the enhanced cell death observed in BLV-infected sheep is abrogated after splenectomy, revealing a key role of the spleen in B-lymphocyte dynamics.<\/jats:p>","DOI":"10.1128\/jvi.01447-06","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T23:43:39Z","timestamp":1164671019000},"page":"11998-12008","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Spleen-Dependent Turnover of CD11b Peripheral Blood B Lymphocytes in Bovine Leukemia Virus-Infected Sheep"],"prefix":"10.1128","volume":"80","author":[{"given":"Arnaud","family":"Florins","sequence":"first","affiliation":[{"name":"Cellular and Molecular Biology, FNRS-FUSAGx, Gembloux, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Gillet","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology, FNRS-FUSAGx, Gembloux, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Becca","family":"Asquith","sequence":"additional","affiliation":[{"name":"Department of Immunology, Imperial College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Debacq","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology, FNRS-FUSAGx, Gembloux, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevie\u0300ve","family":"Jean","sequence":"additional","affiliation":[{"name":"Zootechny Unit, FUSAGx, Gembloux, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Schwartz-Cornil","sequence":"additional","affiliation":[{"name":"U892 INRA, Jouy-en-Josas, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Bonneau","sequence":"additional","affiliation":[{"name":"U892 INRA, Jouy-en-Josas, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arse\u0300ne","family":"Burny","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology, FNRS-FUSAGx, Gembloux, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Reichert","sequence":"additional","affiliation":[{"name":"National Veterinary Research Institute, Pulawy, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Kettmann","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology, FNRS-FUSAGx, Gembloux, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Willems","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology, FNRS-FUSAGx, Gembloux, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504248102"},{"key":"e_1_3_2_3_2","first-page":"1165","volume":"273","year":"2006","unstructured":"Asquith, B., C. 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