{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:12:03Z","timestamp":1790143923886,"version":"4.0.1"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"24","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201400006C"],"award-info":[{"award-number":["HHSN272201400006C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HHSN272201400008C"],"award-info":[{"award-number":["HHSN272201400008C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,11,23]]},"abstract":"<jats:p>The varying influenza A virus (IAV) exposure and infection status of individual swine facilitates introduction, transmission, and dissemination of diverse IAVs. Since agricultural fairs bring people into intimate contact with swine, they provide a unique interface for zoonotic transmission of IAV. Understanding the dynamics of IAV transmission through exhibition swine is critical to mitigating the high incidence of variant IAV cases reported in association with agricultural fairs. We used genomic sequences from our exhibition swine surveillance to characterize the hemagglutinin and full genotypic diversity of IAV at early-season shows and the subsequent dissemination through later-season agricultural fairs. We were able to identify a critical time point with important implications for downstream IAV and zoonotic transmission. With improved understanding of evolutionary origins of zoonotic IAV, we can inform public health mitigation strategies to ultimately reduce zoonotic IAV transmission and risk of pandemic IAV emergence.<\/jats:p>","DOI":"10.1128\/jvi.01453-20","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T13:54:15Z","timestamp":1601387655000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["A Heterogeneous Swine Show Circuit Drives Zoonotic Transmission of Influenza A Viruses in the United States"],"prefix":"10.1128","volume":"94","author":[{"given":"Martha I.","family":"Nelson","sequence":"first","affiliation":[{"name":"Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Perofsky","sequence":"additional","affiliation":[{"name":"Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillon S.","family":"McBride","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-3954","authenticated-orcid":false,"given":"Benjamin L.","family":"Rambo-Martin","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malania M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm","family":"van Bakel","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenab","family":"Khan","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayeeta","family":"Dutta","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Nolting","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0738-8453","authenticated-orcid":false,"given":"Andrew S.","family":"Bowman","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine, Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.56.1.152-179.1992"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau5485"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00502-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16777"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2012.2753"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12193"},{"key":"e_1_3_3_8_2","unstructured":"Marsh B Scheftel J Bender J Blackmore C Bowman AS Burkgren T Calico M Ellis D Finelli L Forshey T Garvey A Kasari E Koeman J Lauxman L Marchall D Paul M Trock S Uyeki TM. 2014. Measures to minimize influenza transmission at swine exhibitions. National Assembly of State Animal Health Officials and National Association of State Public Health Veterinarians."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2009.131082"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv399"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6639a3"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit272"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit649"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6742a3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00822-19"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002077"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.251.6.706"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12574"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-009-0386-6"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12425"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2014.5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1812.121116"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12252"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines3010022"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01439-12"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000924"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01675-15"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12559"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2110.140633"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12270"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/1040638712470449"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-3030-6"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00433-18"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw857"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02005-07"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh340"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl446"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00275-16"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/MRA.00673-19"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vew007"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vey016"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syz020"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000520"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00285-007-0120-8"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v023.i02"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01453-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01453-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:02:05Z","timestamp":1646492525000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01453-20"}},"subtitle":[],"editor":[{"given":"Colin R.","family":"Parrish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,23]]},"references-count":44,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,11,23]]}},"alternative-id":["10.1128\/JVI.01453-20"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01453-20","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,23]]},"assertion":[{"value":"2020-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01453-20"}}