{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:28:13Z","timestamp":1792704493583,"version":"4.5.0"},"reference-count":59,"publisher":"American Society for Microbiology","issue":"23","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204464"],"award-info":[{"award-number":["82204464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073895"],"award-info":[{"award-number":["82073895"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073864"],"award-info":[{"award-number":["82073864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973190"],"award-info":[{"award-number":["81973190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515220126"],"award-info":[{"award-number":["2021A1515220126"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018B030311020"],"award-info":[{"award-number":["2018B030311020"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017369","name":"Scientific and Technological Planning Project of Guangzhou City","doi-asserted-by":"publisher","award":["202002030294"],"award-info":[{"award-number":["202002030294"]}],"id":[{"id":"10.13039\/100017369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2022,12,14]]},"abstract":"<jats:p>PI3K protein has many functions and regulates various cellular processes. As an important regulatory subunit of PI3K, p85\u03b1 can regulate the activity of PI3K signaling.<\/jats:p>","DOI":"10.1128\/jvi.01453-22","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T14:02:47Z","timestamp":1669212167000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["PIK-24 Inhibits RSV-Induced Syncytium Formation via Direct Interaction with the p85\u03b1 Subunit of PI3K"],"prefix":"10.1128","volume":"96","author":[{"given":"Li-Feng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Xiong","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Xing","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Lan","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-3119","authenticated-orcid":true,"given":"Man-Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4682-0261","authenticated-orcid":true,"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou Jinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-013-8368-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12409"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5021"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz683"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00255-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002665"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/a:1010467106305"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.15.6825-6834.2001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.9.7262-7270.1999"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.049254-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2019.04.006"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.26.1.139-141.1988"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-3-9"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.9.5326-5336.2005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.633654"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.535"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.02.008"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0005-2760(98)00139-8"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002165"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.12.003"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.108266"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.132.3.335"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00958-13"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2018.08.013"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00608-20"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01205-21"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.10.010"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800579R"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.509"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2476"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.2.249"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.01.001"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/35044547"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2574"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-020-04740-1"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/v5123192"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003309"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108107200"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5529"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1166"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01882"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108903"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2013.2022"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12212"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2019.06.003"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3590"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201407130"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710751114"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.06.007"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050463"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.29.17582"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.1996.05005.x"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00609-12"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01736-18"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006835"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02547"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606109103"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000141"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01453-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01453-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T14:04:22Z","timestamp":1671026662000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.01453-22"}},"subtitle":[],"editor":[{"given":"Susana","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":59,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2022,12,14]]}},"alternative-id":["10.1128\/jvi.01453-22"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01453-22","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]},"assertion":[{"value":"2022-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01453-22"}}